摘要
目的:探讨双黄连注射剂致过敏性休克的一般规律和特点,以预防或避免其重复发生,促进临床合理用药。方法:通过检索1989年至今维普生物医学全文数据库医药学期刊,收集双黄连注射剂致过敏性休克病案66例,应用文献计量学方法对病案的流行病学资料进行分析。结果:资料中,18～44岁的青年患者比例最高(57.14%);男性21例(58.33%),女性15例(41.67%);患者原发疾病中上呼吸道感染比例最高(65.15%);过敏性休克多发生在给药30min内(93.02%);4例患者抢救无效死亡,死亡率6.06%。结论:双黄连注射剂致过敏性休克的相关因素很多,且后果严重,临床医师、药师应对其加以重视。
OBJECTIVE：To study general rules and the characters of allergic shock caused by shuanghuanglian injection in order to prevent and avoid repeated occurrence of allergic shock and promote rational drug use in the clinic.METHODS：66 cases of allergic shock caused by shuang huanglian injection publicly reported since 1989 have been analyzed by literature metrologic method.RESULTS：There were large proportion of patients at the age of 18 to 44 years old suffered from allergic shock.Among these patients 52.11% were male,47.89% were female.The primary disease associated with allergic shock was upper respiratory tract infection,the occurrence of allergic shock commonly occurred in 30 mins after administration.Four patients died of the terrible allergic shock.CONCLUSION：There are many risk factors related to allergic shock caused by shuang huanglian injection,and the consequence is very serious.The doctors and pharmacists should pay more attention to the adverse reactions of shuang huanglian injection.
出处
《中国医院用药评价与分析》
2010年第4期368-370,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
双黄连注射剂
过敏性休克
不良反应
Shuanghuanglian Injection
Allergic shock
Adverse reaction
