摘要
目的:探讨连续性静脉-静脉血液滤过(CVVH)治疗脓毒性休克的临床疗效。方法:本院综合ICU病房67例脓毒性休克患者分为对照组和治疗组,前者31例常规应用液体复苏、血管活性药物、联合抗感染等治疗,后者36例在常规治疗基础上加CVVH治疗。比较两组患者治疗前后呼吸频率(RR)、心率(HR)、中心静脉压(CVP)、平均动脉压(MAP)、动脉血氧饱和度(SaO_2)、APACHE Ⅱ评分、血尿素氮(BUN)、血肌酐(Cr)、氧合指数(PaO_2/FiO_2)、血乳酸水平和ICU病死率的变化。结果:治疗组的RR、HR、MAP、APACHE Ⅱ评分、BUN、Cr、PaO_2/FiO_2、血乳酸水平和ICU病死率与对照组比较均有显著差异(P<0.05)。结论:在常规治疗的基础上加用CVVH治疗脓毒性休克能有效改善患者的血流动力学,维持内环境稳定,改善组织缺氧,降低病死率。
Objective：To investigate the clinical effects of continuous veno-venous hemofihration （CVVH） in treatment of septic shock. Method：67 patients with septic shock in the intensive care unit （ICU） were divided into either the treatment group（n=36） or the control group（n=31 ）. The control group was received routine therapy methods consist of fluid resuscitation, vasoactive agent, combine anti-infection etc. The treatment group was received the same therapy methods besides CVVH. The respiratory frequency （RR）, heart rate （HR）, central venous pressure（CVP）, mean arterial pressure （MAP）, arterial oxygen saturation（SaO2）, APACHE Ⅱ scores, blood urea nitrogen （BUN）, serum creatinine（Cr）, oxygenation index（PaOJFiO2）, arterial blood lactic acid and mortality were assessed between treatment group and control group. Results：There were significant differences for the RR, HR, MAP, APACHE Ⅱ scores, BUN, serum Cr, PaO2/FiO2, arterial blood lactic acid and mortality between treatment group and control group （P〈0.05）. Conclusion： CVVH therepy could protect the patients with septic shock effectively through improving haemodynamies and tissue hypoxia, sustaining homeostasis and decreasing mortality.
出处
《岭南急诊医学杂志》
2010年第2期73-75,共3页
Lingnan Journal of Emergency Medicine
关键词
连续性血液滤过
连续性血液净化
脓毒性休克
continuous veno-venous hemofihration
continuous blood purification
septic shock
