摘要
目的探讨2型糖尿病合并冠心病的患者胰岛素抵抗(Homa-IR)程度及白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的水平变化在糖尿病冠心病发生、发展中的作用。方法比较50例2型糖尿病并发冠心病患者与50例糖尿病无并发症患者以及50例健康者的生化指标和放免法测定的血清IL-6、TNF-α、Homa-IR指数的差异性。结果2型糖尿病并发冠心病组与无并发症组IL-6、TNF-a和Homa-IR水平比较均显著升高(P<0.01)。且IL-6与Homa-IR、IL-6与TNF-α、Homa-IR与TNF-α成正相关。结论糖尿病合并冠心病者体内相关性指标高表达并与胰岛素抵抗有关。
Objective To investigate the significance of changes of serum IL一6,TNF-a,Homa-IR levels in patients with type 2 diabetes mellitus and coronary heart disease.Methods Serum IL-6,TNF-a,Homa-IR contents were masured in 50 DM2 patients compllcared with CHD,and 48 DM2 patients without CHD,and 50 healthy people.Results The levels of serum IL-6,TNF-a and Homa-IR were also significantly higher in pafien with heart disease than those in patients without heart disease（P0.01）.Conclusion Type 2 diabetics complicated with CHD have increased inflammatory reaction in vivo which is related to the insulin resistance.
出处
《中国临床保健杂志》
CAS
2010年第2期171-172,共2页
Chinese Journal of Clinical Healthcare
