摘要
目的探讨阿司匹林与高血压基底节区脑出血术后再出血的相关性和新鲜血小板、冰冻血小板的疗效。方法开颅手术治疗脑出血816例，未应用阿司匹林的为对照组（A组），应用阿司匹林的随机分为三组：B组常规治疗，c组加用冰冻血小板，D组加用新鲜血小板。排除术中止血不彻底患者（共27例）后，A组315例、B组154例、C组160例、D组160例。结果再出血量、死亡率及ADL评分：B组与A、C、D组比较差异有统计学意义（P〈0．01）。A、C、D三组比较差异无统计学意义。结论阿司匹林可增加脑出血术后再出血机会，增加致残率及死亡率；新鲜血小板及冰冻血小板疗效明显，且疗效差异无统计学意义。
Objective To explore the relation and clinical efficiency for fresh apheresis platelets and frozen apheresis platelets between aspirin and relapsing haemorrhage after operation in hypertensive basal ganglia cerebral haemorrhage patients. Methods 816 patients with hypertensive basal ganglia cerebral haemorrhage were treated with craniotomy. Patients without aspirin medication before the onset of the disease were chosen as the control group （group A ）. There were 326 cases in group A. The patients used aspirin before the onset of the disease were randonrly assigned to three groups （ group B, C and D）. The patients in group B were given routine therapy without other intervention. On the basis of routine therapy, the patients in group C were received frozen apheresis platelets, and the patients in group D were received fresh apheresis platelets. Except the patients without satisfactory heamostasis during operation, there were 315 patients in group A, 154 patients in group B, 160 patients in group C and 160 patients in group D. Results The rate of relapsing heamorrhage after operation, heamatoma volume of relapsing haemorrhage, death rate and ADL score grades by 6 months follow - up survey in four groups showed that there were more significant difference between group A and group B, group B and group C, group B and group D （ P 〈 O. O1 ）. There was no significant difference between group A and group C, group A and group D, group C and group D （P 〉0.05）. Conclusion Aspirin can increase the chance of relapsing haemorrhage after operation, disablement rate and death rate in hypertensive basal ganglia cerebral haemorrhage patients. The chance of relapsing haemorrhage after operation, disablement rate and death rate can be decreased after using fresh apheresis platelets and frozen apheresis platelets. There was no significant difference of curative effect between used fresh apheresis platelets and frozen one. Fresh apheresis platelets should be used as a first -line therapy.
出处
《中华神经外科杂志》
CSCD
北大核心
2010年第4期347-349,共3页
Chinese Journal of Neurosurgery
关键词
阿司匹林
高血压基底节区脑出血
术后再出血
新鲜血小板
冰冻血小板
Aspirin
Hypertensive basal ganglia cerebral haemorrhage
Relapsing haemorrhage after operation
Fresh apheresis platelets
Frozen apheresis platelets
