期刊文献+

小肠CYP450酶在药物代谢中的作用 被引量:11

Role of intestinal cytochrome P450s in drug metabolism
下载PDF
导出
摘要 小肠是口服药物的主要吸收器官,同时也是进行药物代谢的重要场所。小肠黏膜上皮细胞含有大量Ⅰ、Ⅱ药物代谢酶,其中以CYP450酶最为重要,参与众多药物的生物转化。小肠CYP450主要有CYP1A1、CYP2C9、CYP2C19、CYP2J2、CYP2D6、CYP3A6种同工酶,其中CYP3A和CYP2C在小肠中表达最高,分别约占CYP450总含量80%和16%。与肝脏相比,小肠CYP450酶活性及其表达更易受到外源性化合物影响。本文重点讨论小肠CYP450s活性与表达及其在药物代谢中的作用以及由CYP450s的诱导或抑制引起的药物相互作用。 The uptake of oral administered drugs primarily occurs in the small intestine,which also has the capability to metabolize drugs.Both phase I and phase II metabolic enzymes were expressed in the intestinal mucosa,and cytochromes P450(CYP450s) are the principle enzymes attributed to the biotransformation of drugs.CYP3A and CYP2C are the most abundant subfamilies,accounting for approximately 80% and 16% of total CYP450s in the intestine.Compared to the liver,the expression and activity of CYP450 enzymes in the intestine was susceptible to inducers or inhibitors,leading to drug-drug interaction.This article reviews the expression of CYP enzymes in small intestine and the role of the gut wall in CYP-mediated xenobiotic metabolism.Possible drug-drug interactions due to induction or inhibition of CYP enzymes in the small intestine are also addressed.
出处 《中国药科大学学报》 CAS CSCD 北大核心 2010年第2期186-192,共7页 Journal of China Pharmaceutical University
关键词 CYP450酶 肠首过代谢 药物相互作用 药物代谢 cytochrome P450 intestinal first-pass metabolism drug interaction drug metabolism
  • 相关文献

参考文献57

  • 1Thelen K, Dressman JB. Cytochrome P450-mediated metabolism in the human gut wall [ J ]. J Pharm Pharmacol, 2009,61 ( 5 ) : 541 -558.
  • 2Kolars JC,Awni WM,Merion RM,et al. First-pass metabolism of cyclosporine by the gut[J]. Lancet,1991,338(8 781 ) :1 488 - 1 490.
  • 3Paine MF, Shen DD, Kunze KL, et al. First-pass metabolism of midazolam by the human intestine [J].Clin Pharmacol Ther, 1996,60( 1 ) :14 -24.
  • 4Harris RZ, Jang GR, Tsunoda S. Dietary effects on drug metabolism and transport[ J]. Clin Pharmacokinet,2003,42( 13 ) : 1 071 - 1 088.
  • 5van den Bosch HM, Bringer M, de Groot PJ,et al. Gene expression of transporters and phase I/II metabolic enzymes in murine small intestine during fasting[J]. BMC Genomics, 2007,8 : 267.
  • 6Seliskar M, Rozman D. Mammalian cytochromes 17450 importance of tissue specificity [ J ]. Biochim Biophys Acta,2007,1 770 ( 3 ) : 458 - 466.
  • 7Wilkinson GR. Drug metabolism and variability among patients in drug response [ J ]. N Engl J Med, 2005,352 ( 21 ) : 2 211 - 2 221.
  • 8Shimada T, Yamazaki H, Mimura M, et al. Interlndividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals : studies with liver microsomes of 30 Japanese and 30 Caucasians [ J ]. J Pharmacol Exp Ther,1994,270(1 ) :414 -423.
  • 9Paine MF, Hart HL, Ludington SS,et al. The human intestinal cytoehrome P450 "pie" [J]. Drug Metab Dispos,2006,34 ( 5 ) :880 - 886.
  • 10Zhang QY, Dunbar D, Ostrowska A, et al. Characterization of human small intestinal cytochromes P-450 [J]. Drug Metab Dispos, 1999,27 ( 7 ) :804 - 809.

同被引文献139

引证文献11

二级引证文献29

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部