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紫杉醇脂质体与紫杉醇联合顺铂治疗晚期非小细胞肺癌对比研究 被引量:25

Comparison of paclitaxel liposome and paclitaxel plus cisplatin in patients with non-small cell lung cancer
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摘要 目的探讨紫杉醇脂质体与紫杉醇联合顺铂治疗晚期非小细胞肺癌(NSCLC)的临床疗效及不良反应。方法晚期NSCLC患者72例,随机分为试验组与对照组,试验组采用紫杉醇脂质体135mg/m2,对照组采用紫杉醇135mg/m2化疗,两组均联合顺铂,21天为1个周期,治疗2个周期后评价疗效。记录近期疗效与治疗期间毒副反应。结果试验组有效率为41.7%(15/36),临床受益率为77.7%(28/36),对照组有效率为38.9%(14/36),临床受益率为72.2%(26/36),两组差异均无统计学意义(P>0.05)。白细胞减少和血小板减少的发生率两组差异无统计学意义(P>0.05),脱发、腹泻、便秘及呼吸困难的发生率两组差异亦无统计学意义(P>0.05),但试验组恶心、呕吐、皮疹、肌肉痛的发生率明显低于对照组(P<0.05)。结论紫杉醇脂质体联合顺铂治疗晚期NSCLC近期疗效确切有效,毒副反应较紫杉醇联合顺铂化疗为轻。 Objective To investigate the efficacy and safety of paclitaxel liposome regimen on non-small cell lung cancer(NSCLC)compared with traditional paclitaxel plus cisplatin(DDP)in patients.Methods Seventy-two NSCLC patients were randomized into a test group,given paclitaxel liposome 135mg/m2 plus DDP 25mg/m2,and a control group,given paclitaxel 135mg/m2 plus DDP 25mg/m2.The two groups received these regiments for 2 cycles.Results The overall response rates were 41.7% vs.38.9%,and the disease control rates were 77.7% vs.72.2% in the test group and control group(P0.05).The rates of neutropenia and thrombocytopenia were not significantly different in the test group and control group whereas more patients in the control group than in the test group suffered from nausea and vomiting,erythra,courbature(P0.05),and the rates of lipsotrichia diarrhoea and dyspnea were similar between the two groups(P0.05).Conclusion Paclitaxel liposome combined with DDP is an effective treatment regimen with lower incidence of side effects,compared with paclitaxel plus DDP.
出处 《临床肿瘤学杂志》 CAS 2010年第4期343-345,共3页 Chinese Clinical Oncology
关键词 非小细胞肺癌 紫杉醇脂质体 紫杉醇 顺铂 化学治疗 Non-small cell lung cancer Paclitaxel liposome Paclitaxel Cisplatin Chemotherapy
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