摘要
目的探讨医院内铜绿假单胞菌(PAE)对碳青霉烯类抗生素的耐药率及其变迁情况,为临床治疗PAE感染提供参考依据。方法用碳青霉烯类抗生素对1999—2008年临床分离的2479株PAE进行药敏实验。结果PAE感染以下呼吸道为主,主要分布在重症监护病房(24.6%)、神经外科(21.8%)等科室。耐药性、多重耐药性和泛耐药PAE的分离率逐年上升,其耐药率也逐年上升。PAE对亚胺培南和美罗培南的10年总平均耐药率分别为29.2%和25.7%。PAE1999年对亚胺培南的耐药率为14.6%,2008年上升到53.8%,差异有统计学意义(P<0.01);PAE2000年对美罗培南的耐药率为0.2%,2008年上升到46.5%,差异有统计学意义(P<0.01)。结论PAE对碳青霉烯类抗生素的耐药性呈明显上升趋势,临床应适当控制碳青霉烯类药物的使用,以有效控制及延缓耐药株的产生。
Objective To investigate the change of resistance of Pseudomonas aeruginosa （PAE） to Carbapenems in hospital so as to guide clinic treatment of PAE infection. Methods Drug sensitivity tests of 2 479 PAE strains clinically isolated during Jan 1999 - Dec 2008 were made for Carbapenems. Results The common site infected by PAE was lower respiratory tract, and the main departments were ICU （ 24. 6% ） and neurosurgery （ 21.8% ）. The isolation rates of PAE with drug resistance, multi - drug resistance and panresistant strains increased steadily in recent years, and so did their drug resistance rates. The resistance rate of Imipenem was 29. 2%, and that of Meropemem was 25.7%. In 1999, the resistant rate of Imipenem was 14. 6% , while it increased to 53.8% in 2008 （P 〈0. 01 ）. In 2000, the resistant rate of Meropemem was 0. 2%, while it increased to 46. 5 % in 2008 （ P 〈 0. 01 ） . Conclusion The resistance rate of PAE to Carbapenems is obviously increasing, in order to control and slow down the occurrence of the resistant strains, the clinical usage of the Carbapenems should be strategically controlled.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第13期1467-1469,共3页
Chinese General Practice
关键词
假单胞菌
铜绿
碳青霉烯类抗生素
耐药性
Pseudomonas aeruginosa
Antimicrobial agent carbapenem
Drug resistance
