摘要
目的:研究奥氮平对伴有严重精神症状的急性谵妄患者的临床疗效。方法:76例确诊为急性谵妄的患者随机分为两组,治疗组39人和对照组37人。在积极治疗原发病的同时,治疗组患者合并使用奥氮平治疗,对照组患者合并使用地西泮治疗。于治疗前,治疗2周,4周后分别使用谵妄评定量表(CAM-CR),临床总体印象量表(CGI)和药物副作用量表给予评分。结果:与治疗前相比,研究组在治疗2周后的CAM-CR和CGI量表评分有明显改善(P<0.05),而对照组改善不明显,有的患者症状加重。经过4周治疗后,研究组患者改善更明显(P<0.01),而对照组亦有明显改善(P<0.01),其中对照组有2例患者死亡。研究组与对照组的药物副作用量表评分无明显差异(P>0.05)。结论:奥氮平对于快速治疗急性谵妄患者有较好的疗效。
Objective： To study of olanzapine treatment of acute delirium in severity psychiatric symptoms associated with clinical efficacy. Methods：76 patients were diagnosed as acute delirium patients were randomly divided into two groups ,the treatment group 39 and the control group 37. In the active treatment of pri- mary disease, while the treatment group of patients olanzapine combination therapy, patients in the control group combined with diasepam treatment. In the treatment of pre - treatment 2 weeks,4 weeks respectively after using the delirium rating scale （CAM - CR）, Clinical Global Impression Scale （CGI） and drug side effects rat- ing scale given. Results： Compared with those before treatment,the Study Group in the treatment of 2 weeks after the CAM - CR and the CGI Scale score significantly improved （P 〈 0.05 ）, while the control group, no obvious improvement, and some patient＇s symptoms increased. After 4 weeks of treatment, the study group of patients improved more significantly （P 〈0.01）,while the control group also improved significantly （P 〈0.01 ） ,in which the control group,2 patients died. Study group and control group of drug side effects rating scale was no significant difference （ P 〉 0.05 ）. Conclusion： Olanzapine for rapid treatment of acute delirium patients have a better effect.
出处
《医学信息（中旬刊）》
2010年第5期1049-1051,共3页
Medical Information Operations Sciences Fascicule
关键词
奥氮平
急性谵妄
临床疗效观察
Acute delirium
Olanzapine
Clinical observation
