摘要
相同药物的不同固体形态往往有不同的理化性质、药效以及制剂制备工艺。常见的固体形态如溶剂化物、盐,因为种类少或适用的药物少而在应用上受到一定的限制,所以种类多、适用范围广的共晶作为可设计的药物固体形态近年来逐渐受到关注。本文介绍了药物共晶的研究进展,包括其形成原理、设计思路、性质以及制备方法,共晶在药物研究领域有很好的应用前景。
Different solid forms of identical drug may have diverse physicochemical properties, therapeutic/ toxicological effects and formulation profiles. Compared to solvates and salts which are limited to small numbers of nontoxic solvents and ionizable drugs, cocrystals represent the very promising designable solid forms of active pharmaceutical ingredients, due to their extensive species and wide application scope. In this article, progress on pharmaceutical cocrystals, including the formation principles, cocrystal design, physicochemical properties and preparation techniques, is addressed. Cocrystals have great potentials in pharmaceutical sciences.
出处
《化学进展》
SCIE
CAS
CSCD
北大核心
2010年第5期829-836,共8页
Progress in Chemistry
基金
国家"重大新药创制"科技重大专项新制剂与新释药系统技术平台(No.2009ZX09310-004)
江苏省自然科学基金项目(No.SBK20080571)资助
关键词
共晶
晶体设计
共晶形成原理
cocrystals
crystal design
cocrystal preparation
