摘要
为了解氯喹联合柳氮磺胺吡啶治疗类风湿关节炎(RA)的远期疗效,对89例疗程在1年以上的RA患者进行1至4年随访,发现不同疗程临床和实验室观察指标与治疗前相比均有明显改善(P<0.001),但不同疗程之间差异无显著性。缓解率在1至4年分别为41.6％,50.0％,46.3％和41.2％,总有效率分别为87.6％,87.5％,82.9％和76.5％。因副作用退出治疗者占17.8％,主要集中在第一年内,2例在缓解3年后复发。认为该联合治疗方法疗效可靠、稳定、副作用少,是理想的RA治疗方案。
In order to evaluate the effect of combined chemical - therapy of salazopyrin and chloroquini on RA, 89 cases of RA were observed for one to four years in this paper. The results showed that both the clinical signs and the experimental data were improved significantly contrasted between the cases treated for 1 to 4 years and that not received treatment yet (P<0. 001 respectively). The remission rates in the cases of RA in different stages of therapy were all above 40% , accompanying with the total effective rates of which above 76. 5% . And the rates of either remission or effect in different stages of treatment were approximate (P>0.05 respectively). 16 cases (16.8%) gave up treatment because of side- effects, which mostly appeared in the early period of therapy (<6months) and disappeared after being stopped taking these drugs. The au-thers consider that the combined chemical - therapy of RA with chloroquini and salazopyrin be a safe, dependable and stable effective means.
