摘要
目前在哺乳动物体内已发现多种肽转运载体,其中研究最为广泛的是PepT1。PepT1属于典型的依质子的寡肽转运体(POT)超家族成员,是一种H^+依赖的、低亲和力/高容量寡肽转运体,主要表达在小肠上皮细胞刷状缘膜上。肠道PepT1除对消化道中蛋白质降解产物二肽、三肽具有转运吸收功能外,肽类似药物和部分细菌产物均可经该载体转运吸收;因此,PepT1在胃肠道中的功能表达变化,对于维持内外环境稳定及药物吸收具有重要的病理生理学意义。本文总结了PepT1的结构特征和功能、分布、转运机制及调控因素,初步探讨了需要进一步深入研究的问题。
Many peptide transporters have been identified in mammals, among which PepT1 has been widely studied. PepT1, a member of proton-coupled oligopeptide transporter (POT) superfamily, is a peptide transporter of low affinity and high capacity and is mainly expressed in the brush border membrane of intestinal epithelial cells. PepT1 plays an important role in the absorption of di/tri-peptide ( the degradation products of protein in intestinal tract). Meanwhile, it mediates the transport of peptide-like drugs and the bacterial products. Therefore, the changes of the functional expression of PepTl in the gastrointestinal tract may dramatically affect the internal and external environmental stability and drug absorption. This paper reviews the structural features and function, distribution, transport mechanisms, and regulatory factors of PepT1.
出处
《中华临床营养杂志》
CAS
2010年第2期115-120,共6页
Chinese Journal of Clinical Nutrition
关键词
寡肽转运体
二/三肽
肠道
调控因素
Oligopeptide
Di/tri-peptide
Intestinal tract
Regulatory factors