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北京市2009年甲型H1N1流感实际感染人数的估算 被引量:27

Estimation on the real number of novel influenza A (H1N1) cases, Beijing, 2009
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摘要 目的估算北京市2009年甲型H1N1流感的实际感染人数。方法采用基于蒙特卡罗方法编制的乘法模型Impact 2009v 1.0软件,根据北京市流感样病例数、流感样病例中甲型H1NI流感阳性率及流感样病例二级以上医院就诊率等参数,估算北京市2009年甲型H1N1流感的实际感染水平。结果经估算,北京市2009年约有180万人(90%CI:146万~230万)已感染甲型H1N1流感,感染率约为11.0%。发现1例实验室确诊病例实际代表167例感染病例。0—4岁组和5~14岁组人群的感染率最高,分别为32.5%和33.3%。结论甲型H1N1流感报告病例仅是实际感染人群中的小部分,估算发病地区实际感染水平具有较强的实际意义。 Objective To estimate the real number of novel influenza A (H1N1) infection in Beijing, 2009. Methods A multiplier model (Impact 2009 v 1.0 software) based on Monte Carlo approach was used to estimate the real number of novel influenza A (H1N1) based on the number of influenza-like illness (ILI) cases, novel influenza A (H1N1) positive rate among ILI cases and rate on clinical visit of ILIs in secondary and tertiary hospitals. Results There were 1.80 million (90%CI: 1.46-2.30) estimated novel influenza A (H1N1) cases in 2009 in Beijing with the rate of infection as 11.0%. One reported case would represent 167 real infections. The highest age groups of infection were 0-4 years and 5-14 years, being 32.5% and 33.3%, respectively. Conclusion Laboratory-confirmed infections with novel influenza A (H1N1) only represented a fraction of the total cases in a population, suggesting that it was imperative to estimate the real number of novel influenza A (H1N1 ) infection.
出处 《中华流行病学杂志》 CAS CSCD 北大核心 2010年第5期497-499,共3页 Chinese Journal of Epidemiology
基金 国家高技术研究发展计划(863计划)(2008AA022416) “十一五”国家科技支撑计划(2009ZX10004-315) 北京市自然科学基金(7082047) 北京市科委科研院所重点研究项目
关键词 甲型H1N1流感 感染 估算 蒙特卡罗方法 Influenza A (H1N1) Infection Estimation Monte Carlo approach
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参考文献10

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