老年脓毒症患者CD14^+单核细胞与HLA—DR抗原的表达及意义
被引量:3
摘要
脓毒症是重症监护病房(ICU)老年危重患者主要的死亡原因之一。近年来研究证实,脓毒症不仅存在促炎及抗炎反应导致的非特异性免疫功能亢进,还存在着特异性免疫抑制,其后果是对感染的易感性增加及加速患者死亡。
出处
《中华微生物学和免疫学杂志》
CAS
CSCD
北大核心
2010年第4期324-325,共2页
Chinese Journal of Microbiology and Immunology
基金
卫生部科学研究基金-浙江省医药卫生重大科技计划2005年度立项课题(WKJ2005-2-035)
参考文献6
-
1Angus DC,Linde-Zwirble WT,Lidicker J,et al.Epidemiology of severe sepsis in the United States:analysis of incidence,outcome,and associated costs of care.Crit Care Med,2001,29(7):1303-1310.
-
2Mant TG,Borozdenkova S,Bradford DB,et al.Changes in HLA-DR expression,cytokine production and coagulation following endotoxin infusion in healthy human volunteers,Int Immunophramacol,2008,8(5):701-707.
-
3Bone RC.Sir Isaac Newton,sepsis,SIRS,and CARS.Crit Care Med,1996,24(7):1125-1128.
-
4冷建杭,韩阳,卓广超,王克义,汪子伟,彭亮,张玉芳.类风湿关节炎患者淋巴细胞协同刺激分子和活化标志的表达及意义[J].中华检验医学杂志,2005,28(2):189-190. 被引量:2
-
5Hynninen M,Pettila V,Takkunen O,et al.Predictive value of monocyte histocompatibility leukocyte antigen-DR expression and plasma interleukin-4 and-10 levels in critically ill patients with sepsis.Shock,2003,20(1):1-4.
-
6Lekkou A,Karakantza M,Mouzaki A,et al.Cytokiue production and manocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections.Clin Diagn Lab Immunol,2004,11 (1):161-167.
二级参考文献6
-
1Skapenko A, Lipsky PE, Kraetsch HG, et al. Antigen-independent Th2 cell differentiation by stimulation of CD28: regulation via IL-4 gene expression and mitogen-activated protein kinase activation. J Immunol, 2001, 166:4283-4296.
-
2Caruso A, Licenziafi S, CoruUi M, et al. Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation. Cytometry, 1997, 27:71-76.
-
3Salomon B, Bluestone JA. Complexities of CD28/B7: CTLA-4 cestimulatory pathways in autoimmunity and transplantation. Annu Rev Immunol, 2001, 19:225-252.
-
4Kuchroo VK, Daa MP, Brown JA, et al. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathways: application to autoimmune disease therapy.Cell, 1995, 80:707-718.
-
5Kitagawa M, Mitsui H, Nakamura H, et al. Differential regulation of rheumatoid synovial cell interleukin-12 production by tumor necrosis factor alpha and CD40 signals. Arthritis Rheum, 1999, 42: 1971-1976.
-
6冷建杭,蒋群芳,姜晓虹,卓广超,王克义,汪子伟.类风湿关节炎血清和滑液Th1/Th2细胞因子的水平及意义[J].浙江临床医学,2004,6(6):457-458. 被引量:6
同被引文献32
-
1冷建杭,韩阳,卓广超,王克义,汪子伟,彭亮,张玉芳.类风湿关节炎患者淋巴细胞协同刺激分子和活化标志的表达及意义[J].中华检验医学杂志,2005,28(2):189-190. 被引量:2
-
2孙健,张葵,陈军浩,孙雪梅.检测外周血单核细胞HLA-DR的表达及临床意义[J].临床检验杂志,2005,23(6):433-434. 被引量:2
-
3姚咏明.免疫功能紊乱在脓毒症发病中的作用及意义[J].中国危重病急救医学,2007,19(3):138-141. 被引量:63
-
4Angus DC, Linde- Zwirble, WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care[J]. Crit Care Med, 2001, 29(7) :1303 -1310.
-
5Mant TG, Borozdenkova S. Bradford DB, et al. Changes in HLA - DR expression, cytokine production and coagulation following endotoxin infusion in healthy human volunteers [J].Int Immunopharmacol, 2008, 8(5) :701 -107.
-
6Monneret G, Venet F. Statins and sepsis: Do we really need to further decrease monocyte HLA - DR expression to treat septic patients [ J ]. Lancet Infect Dis, 2007, 7( 11 ) :697 -699.
-
7Caruso A, Licenziati S, Corulli M, et al. Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation[J]. Cytometry, 1997, 27(1) :71 -76.
-
8Paz A, Fiszer U, Zaborski J, et al. Phenotyping analysis of peripheral blood leukocytes in patients with muhiple sclerosis [J].Eur J Neural, 1999, 6(3) :347 -352.
-
9Schwiebert LM, Schleimer RP, Radka SF, et al. Modulation of MHC class II expression in human cells by dexamethasone[J].Cell Immunol, 1995, 165(1) :12 -19.
-
10Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS[J]. Crit Care Med, 1996, 24(7) :1125 -1128.
引证文献3
-
1周筱琼,严静,于小妹,王强,叶雄伟.老年脓毒症患者活化淋巴细胞的表达及意义[J].中国卫生检验杂志,2010,20(12):3090-3093. 被引量:3
-
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-
3武宇辉,齐颖,马伟科,李雨铮,杨卫国,李成荣.脓毒症患儿CD14^+单核细胞中miR-146a的表达及其临床意义[J].实用临床医药杂志,2017,21(9):119-122. 被引量:2
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-
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-
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-
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-
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-
5兰博,周建勇,周甘平.1例脓毒症伴血小板进行性下降患者的药学监护[J].中南药学,2018,16(1):125-128. 被引量:1
-
6邹艳惠,刘颖,李默郁,陈立涛,张雪莲.冠心病患者CD14基因多态性与超敏C反应蛋白水平的相关性探讨[J].系统医学,2018,3(13):7-8.
-
7段雨辰,黄忠仕,李军,项琳.老年脓毒症的研究进展[J].右江医学,2019,47(3):230-234. 被引量:3
-
8夏文芳,李冰玉,林维山,潘舟,邓志敏,张勇刚.脓毒症的治疗进展[J].医学综述,2019,25(11):2169-2175. 被引量:29
-
9覃桦,吴英林,陈强.乌司他丁与胸腺肽联合应用于脓毒症对血清细胞因子及免疫细胞的影响[J].中外医疗,2019,38(27):20-22. 被引量:2
-
10赵涛,李三喜,谢昌鸿.胸腺肽α1对ICU脓毒症患者免疫功能及血清降钙素原的影响[J].世界临床药物,2019,40(10):723-727. 被引量:5
-
1寿松涛,柴艳芬,崔书章.老年危重患者合并甲状腺功能减退症的临床分析[J].中国综合临床,2005,21(11):983-985. 被引量:4
-
2黄武,刘幼硕,王艳姣,龙利民,李霞,王翼,杨宇.胰岛素泵强化治疗老年危重患者应激性高血糖的优越性[J].中华老年医学杂志,2007,26(8):602-603. 被引量:2
-
3吴晓红,姚光弼.慢性乙肝病人外周血T细胞表面HLA-DR抗原的表达[J].上海免疫学杂志,1989,9(5):279-281. 被引量:2
-
4苏敏,牛恕淼,李恒力,冯学亮,施秉银,高慧.他巴唑和甲状腺素片治疗对甲状腺上皮DR抗原表达的影响[J].中华内分泌代谢杂志,1991,7(4):240-241. 被引量:1
-
5牛楠,曲鹏,徐丹,崔颖,丁彦春,王虹艳,朱宁,陈海英.阿托伐他汀降低急性冠脉综合征患者外周血CD14^+单核细胞表面TLR4的表达[J].中华高血压杂志,2008,16(5):422-426. 被引量:11
-
6林慧君,周永列,吴茅,潘卫昆.重症感染患者外周血CD14^+单核细胞HLA—DR抗原的表达意义[J].国际流行病学传染病学杂志,2008,35(2):95-96. 被引量:2
-
7王冰,任乾,凌海华,谢恳,黎贵才.胰岛素泵对老年危重患者应激性高血糖的影响[J].辽宁医学杂志,2014,28(4):176-178. 被引量:1
-
8赵迎.老年危重患者的心脏情况[J].世界医学杂志,2003,7(1):24-27.
-
9李晓玉,曾薇.ICU老年危重患者深部真菌感染的高危因素分析及防治[J].临床肺科杂志,2008,13(11):1434-1435. 被引量:9
-
10周苏明.重视老年重症患者的疾病复杂性[J].中华老年多器官疾病杂志,2015,14(4):241-242. 被引量:3