摘要
目的了解病毒性脑炎患儿脑脊液中白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平的变化及临床意义。方法采用双抗体夹心酶联免疫吸附法检测80例病毒性脑炎患儿脑脊液急性期和恢复期的IL-6和TNF-α水平,并与25例正常对照组进行比较分析。结果病毒性脑炎患儿脑脊液IL-6和TNF-α的急性期水平分别为(91.4±24.6)ng/L和(53.5±16.2)μg/L,恢复期水平分别为(52.2±10.8)ng/L和(28.3±10.1)μg/L,正常对照组为(50.5±8.7)ng/L和(24.0±6.5)μg/L,病毒性脑炎患儿脑脊液IL-6和TNF-α的急性期水平均明显高于正常对照组(P<0.01);重症组的急性期IL-6和TNF-α水平分别为(105.5±17.4)ng/L和(68.2±15.5)μg/L,轻症组的急性期IL-6和TNF-α水平分别为(74.6±10.7)ng/L和(40.4±13.6)μg/L,重症组的急性期IL-6和TNF-α水平明显高于轻症组(P<0.01)。结论病毒性脑炎患儿脑脊液IL-6和TNF-α的水平均显著升高,其水平与疾病的发生、发展相关。
OBJECTIVE To study dynamic changes and their significance of levels of IL-6 and TNF-α in cerebrospinal fluid in children with viral encephalitis.METHODS The cerebrospinal fluid levels of IL-6 and TNF-α in 80 children cases with viral encephalitis were detected with ELISA,and the levels were compared with 25 normal children.RESULTS The levels of IL-6 and TNF-α in acute stage were（91.4±24.6）ng/L and（53.5±16.2）μg/L,the levels of IL-6 and TNF-α in convalescent stage were（52.2±10.8）ng/L and（28.3±10.1）μg/L,the levels of IL-6 and TNF-α in normal children were（50.5±8.7）ng/L and（24.0±6.5）μg/L,the levels of IL-6 and TNF-α in acute stage were significantly higher than those in normal children（P〈0.01）.The levels of IL-6 and TNF-α in acute stage of severe cases were（105.5±17.4）ng/L and（68.2±15.5）μg/L,the levels of IL-6 and TNF-α in acute stage of mild cases were（74.6±10.7）ng/L and（40.4±13.6）μg/L,The levels of IL-6 and TNF-α in severe cases were significantly higher than those in mild cases（P〈0.01）.CONCLUSIONS The cerebrospinal fluid levels of IL-6 and TNF-α with viral encephalitis raise significantly and their levels are connected with the advance and the condition of viral encephalitis.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2010年第9期1225-1226,共2页
Chinese Journal of Nosocomiology
