摘要
目的探讨麻醉诱导期雷米芬太尼对患者心率变异性(HRV)的影响。方法择期行气管插管全麻患者60例,年龄19～55岁,随机分为三组,每组20例。麻醉诱导时R1组、R2组和R3组分别用雷米芬太尼1、1.5和2μg/kg。记录诱导前(T0)、气管插管前即刻(T1)、气管插管后即刻(T2)及插管后1 min(T3)3、min(T4)、5 min(T5)患者HRV中的低频功率(LF)、高频功率(HF)、标化的低频功率(LFnu)、标化的高频功率(HFnu)、LF/HF比值及SBP、DBP、HR的变化。结果与T0时比较,T1时三组BP均明显降低(P<0.01),而R3组T2～T4时仍明显偏低(P<0.05);R1组T2～T5时HR增快(P<0.05或P<0.01);R1组T1～T5时LF、HF、T5时HFnu明显降低,LF/HF值明显升高(P<0.05或P<0.01)。结论以1.5μg/kg雷米芬太尼麻醉诱导可预防气管插管时血流动力学反应,维持自主神经调节的均衡性。
Objective To investigate the effects of remifentanil on heart rate variability（HRV） during induction of anesthesia. Methods Sixty patients aged 19-55 years old undergoing general anesthesia were randomly divided into 3 groups with 30 cases each. During anesthesia induction, remifentanil 1.0ug/kg was injected in group R1,1.5ug/kg in group R2 and 2.0 ug/kg in group R3. Low frequency（LF）, high frequency （HF）, LFnu, Hfnu and LF/HF ratio were recorded before induction （T0）, before intubation（Tl ）, at 1,3,5 min after intubation （T2, T3, T4, T5 ）. BP and HR were monitored as well. Results Compared to To, BP was decreased significantly at T1 in 3 groups （P〈 0.01） ,which was still lower at T2-T4 in group R3 （P〈0. 05）. HR was increased T2 Ts in group R1 （P 〈0. 05 or P〈0. 01）. LF and HF at T1-T5 ,and HFnu at T5 were lowered with an incresed LF/HF ratio in group R1 （P〈0. 05 or P〈0.01）. Conclusion During anesthesia induction, remifentanil 1.5 ug/kg can blunt hemodynamic response to tracheal intubation and maintain the balance of autonomic nervous systems.
出处
《临床麻醉学杂志》
CAS
CSCD
北大核心
2010年第4期298-300,共3页
Journal of Clinical Anesthesiology
关键词
雷米芬太尼
心率变异性
Remifentanil
Heart rate variability
