摘要
目的 探讨盐酸法舒地尔治疗冠心病不稳定型心绞痛的疗效和安全性.方法 将70例患者分为治疗组和对照组,治疗组在常规治疗基础上予盐酸法舒地尔,观察两组治疗前后的临床疗效和心电图疗效,CRP、BNP值及其他临床状况.结果 治疗组症状和心电图总有效率为91.4%和85.7%,而对照组为71.4%和60.0%,两组比较差异有统计学意义（P〈0.05）.治疗后治疗组心电图与对照组比较,各项指标均明显改善（P〈0.05）,CPR和BNP值与对照组比较下降更明显（P〈0.05）.治疗组心率、血压和肝肾功能、凝血指标在治疗前后比较差异无统计学意义（P〉0.05）.结论 盐酸法舒地尔治疗不稳定型心绞痛有效安全,值得推广和进一步研究.
Objective To investigate the curative effect and safety of fasudil hydrochloride used in unsta- ble angina. Methods 70 cases of unstable angina were divided into two groups which were the treatment group and the control group, the treatment group was treated by fasudil hydrochloride on the base of common treatment. The clinical efficacy of the two groups before and after treatment, including ECG curative effect, CRP, BNP value and other clinical conditions were observed. Results The total effective rate of symptom and ECG in treatment group was 91.4%, 85.7% and the control group was 71.4%, 60.0%, and there was significant difference compar- ing the treatment group with the control group, P〈0.05. After the treatment, each index of ECG improved signifi- cantly compared with the control group, and the CPR, BNP value in treatment group decreased significantly com- paring with the control group, P〈0.05. Heart rate, blood pressure, liver and kidney function and blood coagula- tion index in treatment group had no significant difference before and after treatment. Conclusion The fasudil hy- drochloride in treatment of unstable angina is effective and safe and worth of spreading and further studying.
出处
《中国心血管病研究》
CAS
2010年第5期334-336,共3页
Chinese Journal of Cardiovascular Research
