慢性心力衰竭患者脑钠肽与尿酸水平变化被引量：16

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摘要目的探讨测定慢性心力衰竭（CtiF）患者血浆脑钠肽（BNP）、血清尿酸（UA）水平在临床应用中的意义。方法测定189例CHF患者，按NYHA心功能分级分为Ⅰ、Ⅱ、Ⅲ和Ⅳ级；健康体检者80例作为对照组。测定血浆BNP、血清uA，超声心动图测定心脏左室舒张末期内径（LVEDd）、左室射血分数（LVEF）。结果CHF患者血浆BNP、血清UA显著高于对照组，随着CHF程度的加重而显著增加；CHF患者LVEDd明显高于对照组，而LVEF显著低于对照组（P〈0．05）。相关分析表明，UA和BNP与LVEDd呈明显的正相关，而与LVEF呈明显的负相关。结论血浆BNP和血清UA与心功能具有明显相关性，UA异常是CHF患者代谢障碍的早期信号，BNP反映了CHF导致的血流动力学应激状态的应激程度，两者联合检测对CHF的诊断、疗效评价和预后判断具有重要的意义。

作者施福生

机构地区浙江省天台县平桥医院内利

出处《中国基层医药》 CAS 2010年第9期1200-1201,共2页 Chinese Journal of Primary Medicine and Pharmacy

关键词心力衰竭充血性脑多肽尿酸

分类号 R541 [医药卫生—心血管疾病]

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