摘要
目的应用心肌声学造影评价冠状动脉造影显示冠状动脉狭窄程度在0-Ⅱ级的心绞痛患者的价值。方法选取具有典型心绞痛的临床表现并排除其它疾病,经冠状动脉造影检测冠状动脉狭窄程度为0-Ⅱ级的冠心病住院患者50例,经心肌声学造影（MCE）的同时应用超声心动图得到以下参数：造影剂峰值密度（A）、心肌血流速率（β）、心肌血流容积（MBF MBF=A×β）、左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）、射血分数（EF）、舒张早期峰值血流速度（Emax）、舒张晚期峰值血流速度（Amax）、舒张早期峰值血流速度与舒张晚期峰值血流速度比值（Emax/Amax）、舒张早期血流延迟时间（Dt）。采用定量分析的方法利用统计学方法对相应节段的心肌灌注情况和心脏功能与正常对照组进行比较。结果与正常对照组比较,心绞痛组β及MFB均显著下降β（0.85±0.25和1.47±036）,P〈0.01;MBF（24.45±6.54和45.35±6.25）,P〈0.05,心脏超声心动图在LVEDD、LVSED、EF、Emax、Amax、Emax/Amax、Dt等参数无明显差别（P≥0.05）。结论有明显心绞痛临床表现而冠状动脉造影示冠状动脉狭窄程度0-Ⅱ级的冠心病患者较正常人血流速度减慢的基础上存在着微循环的损伤,但是并没有导致心脏收缩功能异常。MCE可为具有典型的心绞痛表现而冠状动脉造影示冠状动脉狭窄程度在0-Ⅱ级冠心病患者诊断提供了新的诊断依据。
Objective To evaluate of clinical value for coronary heart disease patients who cornary artery＇s internal diameter narrows between 0 and Ⅱ grade with myocardial contrast echocardiography.Methods 50 cases who had typical angina symptoms,the cornary artery＇s internal diameter narrows between 0 and Ⅱ grade with angiography.those patients must removed off anther disease.these parameters such as LVEDD,LVESD,EF,Dt,Emax,Amax,Emax/Amax,A,β and MBF measured with MCE and echocardiogram.compare perfusion flow and cardiac function with normal team by science of statistics.Results β and MBF was found descend than normal team.There was no significant difference in LVEDD,LVESD,EF,Emax,Amax,Emax/Amax,and Dt.Conclusion MCE can evaluate regional myocardial perfusion and microcirculation.the patients who cornary artery＇s internal diameter narrows in o to Ⅱgrade by angiography exist blood flow velocity decrease and microcirculation damage but the cardiac function was normal.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2010年第2期185-188,共4页
Journal of Harbin Medical University
关键词
心肌声学造影
冠心病
心肌微循环
心脏功能
myocardial contrast echocardiography
coronary heart disease
myocardial microcirculation
caradiac function
