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类风湿关节炎治疗进展 被引量：19

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摘要 近20年来类风湿关节炎（RA）的诊治水平迅速提高，特别是生物制剂的应用使RA的治疗备受关注。2008年，美国风湿病学会（ACR）从循证医学的角度提出了RA患者使用非生物制剂类和生物制剂类改善病情的抗风湿药（DMARDs）的治疗建议^[1]。
作者 张文 赵岩
机构地区 中国医学科学院北京协和医学院北京协和医院风湿免疫科
出处 《中华内科杂志》 CAS CSCD 北大核心 2010年第5期448-450,共3页 Chinese Journal of Internal Medicine
关键词 类风湿关节炎 治疗 美国风湿病学会 生物制剂 RA患者 抗风湿药 循证医学
分类号 R593.22 [医药卫生—内科学]
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参考文献12

  • 1Sang KG,Teng GG,Patkar NM,et al.American College of Rheumatology 2008 recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis.Arthritis Rheum,2008,59:762-784.
  • 2van Vollenhoven RF.Treatment of rheumatoid arthritis:state of the art 2009.Nat Bey Rheumatol,2009,5:531-541.
  • 3Rantalaiho V,Korpela M,Hannonen P,et al.The good initial response to therapy with a combination of traditional diseasemodifying antirheumatic drugs is sustained over time:the elevenyear results of the Finnish rheumatoid arthritis combination therapy trial.Arthritis Rheum,2009,60:1222-1231.
  • 4Goekoop-Ruiterman YP,de Vries-Bouwstra JK,Allaart CF,et al.Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study):A randomized,controlled trial.Arthritis Rheum,2008,58 (2 Suppl):S126-135.
  • 5Sokka T,Envalds M,Pincus T.Treatment of rheumatoid arthritis:a global perspective on the use of antirheumatic drugs.Med Rheumatol,2008,18:228 -239.
  • 6Goekoop-Ruiterman YP,de Vries-Bouwstra JK,Kerstens PJ,et al.DAS-driven therapy versus routine care in patients with recentonset active rheumatoid arthritis.Ann Rheum Dis,2010,69:65-69.
  • 7Keystone EC,Kavanangh AF,Sharp JT,et al.Radiographic,clinical,and functional outcomes of treatment with adalimumab (a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy:a randomized,placebo-controlled,52-week trial.Arthritis Rheum,2004,50:1400-1411.
  • 8Burmester GR,Mariette X,Montecucco C,et al.Adalimumab alone and in combination with disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis in clinical practice:the Research in Active Rheumatoid Arthritis (ReAct) trial.Ann Rheum Dis,2007,66:732-739.
  • 9黄烽,张奉春,鲍春德,陶怡,古洁若,徐建华,朱平,徐沪济,张志毅,赵东宝,吴东海.阿达木单抗联合甲氨蝶呤治疗类风湿关节炎的多中心、随机、双盲、安慰剂对照临床研究[J].中华内科杂志,2009,48(11):916-921. 被引量：15
  • 10Keystone E,Fleischmann R,Emery P,et al.Safety and efficacy of additional courses of rituximab in patients with active rheumatoid arthritis:an open-label extension analysis.Arthritis Rheum,2007,56:3896-3908.

二级参考文献8

  • 1Zeng QY, Chen R, Darmawan J, et al. Rheumatic diseases in China. Arthritis Res Ther,2008,10 : R17.
  • 2Sangha O. Epidemiology of rheumatic diseases. Rheumatology (Oxford) ,2000,39 Suppl 2:3-12.
  • 3Feldmann M, Brennan FM, Maini RN. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol, 1996,14:397-440.
  • 4Kwak HB, Jin HM, Ha H, et al. Tumor necrosis factor-alpha induces differentiation of human peripheral blood mononuclear cells into osteoclasts through the induction of p21 ( WAF1/Cipl ). Biochem Biophys Res Commun,2005,330 : 1080-1086.
  • 5Zou W, Hakim I, Tschoep K, et al. Tumor necrosis factor-alpha mediates RANK ligand stimulation of osteoelast differentiation by an autocrine mechanism. J Cell Biochem,2001,83:70-83.
  • 6Zhang YH, Heulsmann A, Tondravi MM, et al. Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis via coupling of TNF type 1 receptor and RANK signaling pathways. J Biol Chem,2001, 276:563-568.
  • 7Kim HY, Lee SK, Song YW, et aL A randomized, double-blind, placebo-controlled, phase Ⅲ study of the human anti-tumor necrosis factor antibody adalimumab administered as subcutaneous injections in Korean rheumatoid arthritis patients treated with methotrexate. APLAR J Rheumatol, 2007,10:9-16.
  • 8Keystone EC, Kavanaugh AF, Sharp JT, et al. Radiographic, clinical, and functional outcomes of treatment with adalimumab ( a human anti-tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy : a randomized, placebo-controlled, 52-week triM. Arthritis Rheum ,2004,50 : 1400-1411.

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中华内科杂志
2010年 第5期

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