摘要
目的:观察帕罗西汀治疗非便秘型肠易激综合征的临床疗效。方法:符合罗马Ⅲ诊断标准的非便秘型肠易激综合征患者107例,随机分为2组,治疗组57例,给予帕罗西汀20 mg,每日晨起顿服,匹维溴铵50 mg,3次/d,口服;对照组50例,给予谷维素30 mg,3次/d,口服,匹维溴铵50 mg,3次/d,口服,疗程4周。观察患者腹痛、腹泻、腹部不适、排便次数、大便性状,以及焦虑、抑郁等改善情况。结果:治疗组总有效率为93.0%,对照组总有效率为76.0%,两组比较差异有统计学意义(P<0.01)。结论:帕罗西汀治疗非便秘型肠易激综合征有明确的临床意义。
Objective： Therapeutic observe the clinical effect of Paroxetin for irritable bowel syndrome（IBS） of non-constipation type.Methods： A total of 107 patients with IBS of non-constipation were randomly divided into two groups.There were 57 cases in the treatment group and 50 cases in the control group.All 107 cases accordwith diagnostic standard of Rome Ⅲ.For the treatment group,the patients were given paroxetin 20 mg every morning and pinaverium bromide 50mg three times per day.For the control group,the patients were given oryzanol 30 mg three times per day and pinaverium bromide 50 mg three times a day.The period of treatment is four weeks.The bellyache,diarrhea,comfortlessness of belly,the times of stool,the shape of stool,the situation of anxiety and depression were observed for all these cases.Results： The response rate of the treatment group was 93.0%,but that of the control group was 76.0%.The difference between the two groups was statistically significant（P〈0.01）.Conclusion： Paroxetin has distinct therapeutic efffect for irritable bowel syndrome of non-constipation type.
出处
《华西医学》
CAS
2010年第1期37-38,共2页
West China Medical Journal
关键词
帕罗西汀
肠易激综合征
临床观察
paroxetin
irritable bowel syndrome
clinic observation
