摘要
目的中草药对胃癌有抑制作用，但其作用的有关机制尚不清楚，通过诱发大鼠胃癌模型，研究复方参七汤对胃癌的抑制作用．方法采用Ｎ甲基Ｎ＇硝基Ｎ亚硝基胍（ＭＮＮＧ）１００ｍｇ／Ｌ连续喂养Ｗｉｓｔａｒ大鼠９ｍｏ，制成胃癌模型，实验大鼠在喂养ＭＮＮＧ的同时，连续喂给中药复方参七汤１８ｍＬ／ｋｇ．观察实验组和对照组胃癌的发生率．结果实验组胃癌发生率为６９％（３／４３），对照组胃癌发生率为５８９％（２３／３９）．两组比较有显著差异（Ｐ＜００１）．结论复方参七汤能显著降低ＭＮＮＧ诱发的大鼠胃癌发生率，对胃癌有明显的抑制和预防作用．
AIM Chinese herbal medicine has an inhibitory effect on gastric carcinoma. The mechanisms for this effect remain unknown. The aim of this study is to establish the animal model of gastric adenocarcinoma by N methyl N' nitro N nitrosoguanidine (MNNG) and to study the inhibitory effect of fufangshenqitang (FFSQT) on gastric adenocarcinoma. METHODS One hundred Wistar rats were given 100mg/L of MNNG for nine months and 1mL/week saturated solution of sodium chloride (NaCl) in the first six weeks, to establish the animal model of gastric adenocarcinoma. Meanwhile, each rat of experiment group was given 18mL/kg FFSQT. After nine months the incidence of induced gastric adenocarcinoma in two groups was observed. RESULTS The incidence of gastric adenocarcinoma of experiment group was 6 9% (3/43) and that of control group was 58 9% (23/39). There was a significant difference in the incidence of gastric adenocarcinoma between the two groups ( P <0 01). CONCLUSION Prolonged administration of FFSQT results in a significant reduction in the incidence of stomach cancer on Wistar rats induced by MNNG. FFSQT has obviously preventive as well as inhibitory effects against gastric adenocarcinoma.
出处
《世界华人消化杂志》
CAS
1999年第2期117-119,共3页
World Chinese Journal of Digestology
基金
江苏省中医管理局资助课题
关键词
胃肿瘤
复方参七汤
疾病模型
stomach neoplasms/therapy
drugs, Chinese herbal medicine
disease models, animal
