摘要
目的探讨运动意向的形成、执行和抑制过程的神经相关。方法记录14名在校大学生在完成意向准备与执行两阶段任务时的19通道事件相关电位（event—related potentials，ERP）和行为反应。首先在意向准备阶段呈现“做什么”（what）线索，分为3类：（1）指令性或（2）自由性意向准备左手或右手按键反应，（3）对照情形无须意向准备。随后在意向执行阶段呈现“是否做”（whether）线索，受试者将（1）强制性或（2）自主性执行或放弃先前的运动意向。结果平均反应时的“做什么”和“是否做”交互效应显著（P（2,26）=8．262，P=0．002）。其中，指令意向条件下的强制反应[（466．60±106．38）ms]显著快于自主反应[（545．35±147．06）ms]，自由意向条件下的强制反应[（538．71±127．39）ms]与自主反应[（561．44±146．51）ms]无显著差异，无意向准备（对照）条件下的强制反应[（533．80±81．71）ms]快于自主反应[（589．75±140．81）ms]。在意向形成阶段，自由性和指令性的ERP效应主要出现在双额部（150～200ms）、广泛额顶部和右侧颞区（300～700ms）。在意向执行阶段，自主执行与自主抑制的ERP效应出现在左前额及额顶中央区（160～220ms），右前额顶区（300～550ms）。结论自由性运动意向产生于前额部，运动意向在额顶网络维持。早期的意向抑制涉及左前额及额顶中央区，而右额顶区与晚期的反应抑制相关．
Objective To investigate neural correlates of the generation, execution and inhibition of motor intention. Methods Behavioral performance and event-related potentials （ERP） of 14 participants were recorded when they performed a two-staged Go-Nogo task. At the stage of intention preparation,three kinds of the ＂what＂ cues were presented separately to the participants ： （ 1 ） to press a response key by the left or the right hand （ the instructed） , （2） to decide freely which hand will be used （the free） , （3） to wait for the second cue （the con- trol）. At the stage of intention execution,the ＂whether＂ cue suggested the participants execute （Go） or withdraw （Nogo） the previous intention either voluntarily or foreedly. Results The interaction effect between the ＂what＂ and the ＂whether＂ was significant （F（2,26） = 8. 262, P = 0. 002 ）. The forced responses were faster than those of vol- untary action under both the instructed condition （ （468.52 ± 105.87 ）ms vs （546.67 ± 146.33 ）ms） and the con- trol condition （（536.78 ± 83.28 ）Ins vs （589.75± 140.80）ins）. No significant difference was found for the free condition（ （538.71 ±127.39 ） ms vs （561.44±146.51 ） ms）. At the stage of intention preparation, significant ERP effects between the instructed intention and the freely intention were revealed in bilateral frontal regions （ 150 -200 ms）,frontoparietal area （300 -700 ms）and right temporal area. At the stage of intention execution, ERP effects between voluntary inhibition and voluntary action were observed in left prefrontal area （160 - 220 ms ） , fro- nto-eento-parietal area and right frontoparietal area. （300 -550 ms ）. Conclusion The motor intention may be generated in the prefrontal area and maintained in the frontoparietal network. The left prefrontal and fronto-eentro- parietal areas inhibit intention in the early stage and the right frontoparietal area involves response inhibition lately.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2010年第5期436-439,共4页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金资助项目（30270468）
关键词
运动意向
自主抑制
事件相关电位
Motor intention
Voluntary inhibition
Event-related potentials
