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低剂量化疗在肺癌治疗中的研究进展 被引量:8

Research progress of low-dose chemotherapy in treatment of lung cancer
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摘要 化疗是肿瘤综合治疗的主要方式之一,多年来在肿瘤治疗中发挥着重要作用。但近年来低剂量化疗以其利用化疗药物的新靶点、采取合理的给药方式和计划,且相对于最大耐受量化疗具有毒副反应小、患者耐受性明显提高、疗效更佳等优势,已逐渐成为肺癌治疗研究的热点和新策略。本文就低剂量化疗的起源、作用机制、优势及存在问题等方面的研究进展作~综述。 Chemotherapy is one of the main ways of comprehensive treatment of tumor,and it has played an important role in the treatment of tumor for many years. In recent years, low-dose chemotherapy has been a hot research and new strategy in the treatment of lung cancer, because it uses new target of chemotherapy drugs, takes reasonable manner of administration and plan, and has fewer toxic side effects, higher patient tolerance and better therapeutic effect compared with the maximum tolerated dose chemotherapy. This article reviews the research progress on the origin, mechanism, predominance and problems of low-dose chemotherapy.
出处 《国际呼吸杂志》 2010年第10期626-630,共5页 International Journal of Respiration
关键词 化疗 低剂量 肿瘤 肺癌 Chemotherapy Low-dose Tumor Lung cancer
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参考文献27

  • 1Kerbel RS,Klement G,Pritchard KI,et al.Continuous low-dose anti-angiogenic/metronomic chemotherapy:from the research laboratory into the oncology clinic.Ann Oncol,2002,13:12-15.
  • 2Browder T,Butterfield CE,Kraling BM,et al.Antiangiogenic scheduling of chemotherapy improves efficacy against experimental drug-resistant cancer,Cancer Res,2002,60:1878-1886.
  • 3陶维阳,姜洪池.节律性化疗的研究进展[J].现代肿瘤医学,2008,16(8):1421-1424. 被引量:2
  • 4Stempak D,Gammon J,Halton J,et al.A pilot pharmacokinetic and antiangiogenic biornarker study of celecoxib and low-dose metronomic vinblastine or cyclophosphamide in pediatric recurrent solid tumors.J Pediatr Hematol Oncol,2006,28:720-728.
  • 5厉明,梅同华,张明川,李长毅.CTX小剂量化疗在抗肺癌血管生成中的作用[J].肿瘤,2007,27(7):523-526. 被引量:2
  • 6Hanahan D,Bergers G,Bergsland E.Less is more,regularly:metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice.J Clin Invest,2002,105:1045-1047.
  • 7Bocci G,Nicolaou KC,Kerbel RS.Protracted low-dose effects on human endothelial cell proliferation and survival in vitro reveal a selective antiangiogenic window for various chemotherapeutic drugs.Cancer Res,2002,62:6938-6943.
  • 8Emmenegger U,Man S,Shaked Y,et al.A comparative analysis of low-dose metronomic cyclophosphamide reveals absent or low-grade toxicity on tissues highly sensitive to the toxic effects of maximum tolerated dose regimens.Cancer Res,2004,64:3994-4000.
  • 9Bertolini F,Paul S,Mancuso P,et al.Maximum tolerable dose and low-dose metronomic chemotherapy have opposite effects on the mobilization and viability of circulating endothelial progenitor cells.Cancer Res,2003,63,4342-4346.
  • 10Bocci G,Francia G,Man S,et al.Thrombospondin 1,a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy.Proc Natl Acad Sci USA,2003,100:12917-12922.

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