摘要
氯吡格雷是一种抗血小板药物,是新型二磷酸腺苷受体拮抗剂,已广泛应用于各种血栓性疾病尤其是急性冠脉综合征和经皮冠状动脉介入治疗术后的抗血栓治疗。但近年来,在长期随访中研究发现,部分患者存在氯吡格雷抵抗现象,即应用氯吡格雷治疗的患者仍会发生心血管血栓事件。本文就氯吡格雷的作用机制、氯吡格雷抵抗定义、氯吡格雷抵抗的发生机制及临床意义等作一综述。
Clopidogrel is a antiplatelet drug and a new ADP receptor antagonist. It has been widely used in patients with acute coronary syndrome （ACS） and antithrombotic therapy in patients after percutaneous coronary intervention （PCI）. But in recent years the long - term follow - up studies show that some patients have clopidogrel resistance which means that cardiovascular events still occur among these patients treated by elopidogrel. This paper reviews mechanisms to clopidogrel. And concept, pathogenesis and clinical significance of clopidogrel resistance are also discussed in the article.
出处
《国际老年医学杂志》
2010年第3期124-128,共5页
International Journal of Geriatrics
关键词
氯吡格雷
氯吡格雷抵抗
二磷酸腺苷受体拮抗剂
Platelet
Clopidogrel
Clopidogrel resistant
ADP receptor antagonist
Acute coronary syndrome
