摘要
埃兹(Ezrin)蛋白是埃兹蛋白、根蛋白、膜突蛋白(ezrin—radixin—moesin,ERM)家族重要成员之一,连接于细胞膜与细胞骨架之间,在维持细胞的形状、极性、运动以及信号转导方面发挥着重要作用。近年研究发现,埃兹蛋白在多数肿瘤细胞中异常高表达,在肿瘤癌变、肿瘤细胞浸润和转移中起重要作用。
Ezrin is a member of ezrin-radixin-moesin(ERM) family acting as correlationship between plasma membrane and cytoskeleton, which plays an important role in maintaining shape, polarity, and movement as well as signal transduction of ceils. The recent studies indicate that Ezrin abnormally overexpresses in majority of tumor cells, which has close relationship with carcinogenesis, invading and metastasis of tumor cells.
出处
《国际肿瘤学杂志》
CAS
2010年第3期170-172,共3页
Journal of International Oncology
基金
基金项目:国家自然科学基金(30572455,30973400)
教育部新世纪优秀人才支持计划(NCET-06-0685)
关键词
磷蛋白类
肿瘤转移
Phosphoproteins
Neoplasm metastasis