摘要
目的:探讨腹腔镜联合大剂量甲氨蝶呤(MTX)治疗宫外孕的临床疗效及安全性。方法:76例宫外孕患者随机分为治疗组(36例)和对照组(40例)。治疗组采用腹腔镜手术联合大剂量MTX治疗,对照组采用大剂量MTX治疗。连续治疗14天后评价临床疗效,观察治疗后第7天血β-HCG下降率,观察血β-HCG下降至正常所需要时间及宫内妊娠率。结果:治疗组临床疗效总有效率为97.2%,显著高于对照组(P<0.05);治疗后第7天治疗组血β-HCG下降率显著高于对照组,相比较有统计学差异(P<0.05);治疗组血β-HCG下降到正常所需要的时间显著低于对照组,相比较有统计学差异(P<0.05);治疗组1、2、3年的宫内妊娠率显著,分别为41.7%、61.1%、77.8%,显著高于对照组(P<0.05);两组均无明显不良反应。结论:腹腔镜手术联合大剂量MTX保守治疗宫外孕的疗效确切、安全、可靠,值得临床上推广应用。
Objective：To evaluate the clinical efficacy and safety of laparoscopic combined with high dose methotrexate （MTX） treatment of ectopic pregnancy.Methods：76 patients with EP were randomly divided into treatment group （36 cases） and control group （40 cases）.The treatment group was treated with laparoscopic surgery and high-dose MTX treatment,the control group was treated with high-dose MTX.After 14 days of continuous treatment the clinical efficacy was evaluated. In the 7th day after treatment the decline rate of serum β-HCG,the time-consuming of serum β-HCG decreased to normal levels and intrauterine pregnancy （IUP） rate were observed.Results：The clinical total effective rate of the treatment group was 97.2%,it was significantly higher than that of the control group （P0.05）. In the 7th day after treatment the decline rate of serum β-HCG of treatment group was significantly higher than that of the control group （P0.05）,the time-consuming of serum β-HCG decreased to normal levels in the treatment group was significantly lower than that in the control group （P0.05）; the IUP rate of the treatment group in the 1,2,3-year was respectively 41.7%,61.1% and 77.8%,they were significantly higher than that of the control group （P0.05）.There were no obvious side effects in the two groups.Conclusion：The conservative treating EP with laparoscopic combined with high dose methotrexate （MTX） has curative effect,it is safe,reliable and worthy of clinical application.
出处
《中国妇幼保健》
CAS
北大核心
2010年第14期1919-1921,共3页
Maternal and Child Health Care of China
关键词
宫外孕
腹腔镜手术
大剂量MTX
Ectopic pregnancy
Laparoscopic surgery
High-dose methotrexate
