摘要
目的观察靶控输注丙泊酚联合氟比洛芬酯在无痛人工流产手术中的应用效果。方法选择ASAⅠ～Ⅱ级行无痛人工流产手术患者100例,随机均分为2组,每组50例。A组先静脉注射氟比洛芬酯50mg,B组先静脉注射生理盐水5ml,5min后两组丙泊酚血浆浓度设为3.5g.L-1静脉泵注。观察术前、睫毛反射消失时、扩宫时、吸宫时和手术结束时的平均动脉压(MBP)、心率(HR)、潮气量(TV)、呼吸次数(RR)、脉搏血氧饱和度(SpO2),诱导时间、手术时间、唤醒时间、异丙酚总用量、患者术中体动次数及术后宫缩痛的视觉模拟评分(VAS)。术后由手术医生评定麻醉效果。结果诱导时间、丙泊酚总用药量、唤醒时间、术中体动次数A组明显优于B组(P<0.05)。二组病人睫毛反射消失和扩宫时MAP、HR、TV、RR均明显低于术前(P<0.05)。扩宫时B组潮气量(TV)、呼吸次数(RR)明显低于A组(P<0.05)。麻醉效果达优者B组明显少于A组(P<0.05),术后宫缩痛VAS评分A组明显优于B组(P<0.05)。结论靶控输注丙泊酚联合氟比洛芬酯用于无痛人工流产手术麻醉效果确切、诱导快速、唤醒迅速、呼吸抑制减少、术后宫缩痛明显缓解。
Aim To observe the effect of anesthesia with propofol target-controlled infusion and flurbiprofen axetil in painless artificial abortion.Method One hundred patients（ASAⅠ～Ⅱ）were randomly divided into 2 groups.The women in group A（50 cases）accepted flurbiprofen axetil 50mg and the women in group B（50 cases）accepted physiologic saline 5ml.After 5 minutes later,the target plasma propofol concentration of two groups set at 3.5 mg·L^-1.The value of mean arterial pressure（MAP）,heart rate（HR）,tidal volume（TV）,respiration rate（RR）and pules oxygen saturation（SpO2）,induction time,operation time,awake time,propofol dosage,patients＇ body motion and the visual analog scales（VAS）of postoperative uterine contraction pain were observed.The analgesia effect was judged by operation doctors.Results Induction time,propofol dosage,awaken time and the frequency of body motion in Group A was better than that in Group B significantly（P〈0.05）.In both groups,the value of mean arterial pressure（MAP）,heart rate（HR）,tidal volume（TV）and respiration rate（RR）at the vanishing of eyelash reflex and dilatation of cervix was lower than that at pre-operation significantly（P〈0.05）.The value of tidal volume（TV）and respiration rate（RR）in Group B was less than that in Group A at dilatation of cervix significantly（P〈0.05）.Fewer patients in Group B showed a good level anesthesia effect than that in Group A significantly（P〈0.05）.The visual analog scales（VAS）of postoperative uterine contraction pain in Group A was better than that in Group B significantly（P〈0.05）.Conclusion Target-controlled Infusion with Propofol and flurbiprofen axetil give more efficient anesthesia,faster induction and better recovery with few complications.In the meanwhile,the respiratory depression appeared less and postoperative uterine contraction pain much alleviated.
出处
《安徽医药》
CAS
2010年第6期706-707,共2页
Anhui Medical and Pharmaceutical Journal
关键词
靶控输注
丙泊酚
氟比洛芬酯
人工流产
target-controlled infusion
propofol
flurbiprofen axetil
artificial abortion
