摘要
目的:比较国产生物可降解希罗莫司支架(EXCEL)与进口永久聚合物希罗莫司支架(CYPHER)在冠心病患者中应用的安全性及有效性。方法:回顾分析同期植入EXCEL支架治疗的230例和植入CYPHER支架的161例冠心病患者,对比分析两组患者PCI操作成功率、术后1年内主要不良心脏事件(MACE)发生率及支架内血栓事件发生率。结果:两组在基本临床情况、冠脉病变特征及主要介入技术指标等方面均无统计学差异;两组手术操作成功率分别为99.6%和99.4%;术后随访1年MACE发生率EXCEL组(5.8%)略高于CYPHER组(4.6%),但两组比较差异无统计学意义(P>0.05);CYPHER组支架内血栓事件发生率0.7%,而EXCEL组术后无支架内血栓事件发生,但两组比较差异无统计学意义(P>0.05)。结论:生物可降解希罗莫司涂层支架(EXCEL)治疗冠心病安全有效,各项指标与CYPHER支架相比无明显差异。
Objective:To compare the safety and efficacy of biodegradable polymer sirolimus-eluring stent (EXCEL) and durable polymer sirolimus-eluting stents (CYPHER) in the treatment for coronary artery disease. Methods: This is a retrospective case-control study in a single centre. A cohort of 230 patients with CAD treated with EXCEL stent and a subset of 161 CAD patients treated with CYPHER stent from January 2007 to April 2008 were followed up. The results from 12 months of follow- up were analyzed by comparing procedural success rate, MACE and stent thrombosis. Results: Two groups were similar in main baseline clinical data and major angiography characteristics. The procedural success rate was 99.6% in EXCEL group and 99.4% in CYPHER group, respectively (P〉0.05). The incidence of MACE at one-year follow-up was 5. 8% in EXCEL group and 4.6% in CYPHER group (P〉 0.05). Stent thrombosis occurred in 1 patient (0.7%) in CYPHER group and in no patient in EXCEL group, without significant difference (P〉0.05). Conclusion:Implantation of the EXCEL stent in patients with coronary artery disease is safe and effective, with no difference compared with that of the CYPHER stent in one-year follow-up outcomes.
出处
《国际心血管病杂志》
2010年第3期183-185,共3页
International Journal of Cardiovascular Disease