摘要
目的:研究五眼果水提物对小鼠泌尿系统结石的影响。方法:以诱石液为1%乙二醇和1α(OH)VitD3造成小鼠泌尿系统结石模型,给予五眼果水提物干预后,测定尿中和肾脏的草酸、钙含量。结果:与空白组比较,模型组尿草酸明显升高(P<0.05)。给药后,结果显示,五眼果水提物高、中剂量组的尿草酸、尿钙在实验期间均明显降低(P<0.05),低剂量组的尿草酸、尿钙在给药后第3、4周也有明显降低(P<0.05);对肾草酸、肾钙均有明显降低作用(P<0.05)。结论:五眼果水提物对小鼠泌尿系统结石具有显著的作用。
AIM：To study the effects of water extraction of Choerospondias axillaris on inhibiting renal calculus. METHODS：The mice were fed 1% ethylene alcohol and 1α（OH）VitD3 to cause renal calculus. The concentrations of calcium and oxalate acid in urine and kidney were determined in mice to evaluate the effects of Choerospondias axillaris. RESULTS：The urinary oxalate of model group （1% ethylene glycol and 1α（OH） VitD3） increased significantly（P 0. 05） as compared with the control group. Choerospondias axillaris groups demonstrated obviously the decrease in concentration of oxalic acid and calcium in urine and kidney. CONCLUSION：Choerospondias axisllaris has a good effect on the treatment of renal calculus.
出处
《中成药》
CAS
CSCD
北大核心
2010年第5期719-722,共4页
Chinese Traditional Patent Medicine
基金
广西高校人才小高地建设创新团队计划资助(桂教人(2005)80)
关键词
五眼果
泌尿系统结石
动物实验
Choerospondias axillaris
urinary tract stones
animal experiment
