摘要
目的探讨中药注射剂引起过敏性休克的危险因素,进一步为中药注射剂引起过敏性休克危险因素的综合防治措施提供依据。方法采用病例对照研究的方法,对过敏性休克患者和对照组共271例进行了性别、年龄、用药剂量、输液种类、输液浓度、合并用药、过敏发生时间、过敏史等调查;通过非条件Logistic回归模型进行单因素与多因素的分析。结果经单因素分析和多因素分析结果显示,年龄、输液浓度、过敏发生时间在中药注射剂引起过敏性休克有显著性(P<0.05),其OR值分别为:1.671,3.048,5.394、2.620。结论年龄、输液浓度、过敏发生时间为中药注射剂引起过敏性休克的危险因素。
Objective To investigate the risk factors of Chinese herb injection-induced anaphylactic shock,so as to provide evidence for further monitoring. Methods The information on sex,age,infusion concentration and dosage,the time and history of allergic reaction of 271 new cases of anaphylactic shock and controls was collected by case-control method.The univariate and multivariate analysis was done through logistic regression model.Results By univariate and multivariate analysis,the major risk factors on the development of Chinese herb injection-induced anaphylactic shock include age,infusion concentration,the time of allergic reaction,with OR value 0.502,1.299;1.701,2.671;0.571;5.211,2.637,0.738,respectively.Conclusion The risk factors on the development of Chinese herb injection-induced anaphylactic shock include age,infusion concentration,and the time of allergic reaction.
出处
《今日药学》
CAS
2010年第5期42-45,共4页
Pharmacy Today
