摘要
目的探讨西酞普兰与氯米帕明治疗难治性强迫症的疗效和不良反应。方法将难治性强迫症患者64例随机分为两组,分别用西酞普兰与氯米帕明治疗8周。采用强迫症量表(Y-BOCS)和不良反应量表(TESS)评价疗效及不良反应。结果两组治疗后4、6、8周Y-BOCS评分均较治疗前下降(P<0.05);治疗后4、6、8周末比较,差异均无统计学意义(P>0.05);两药的总体疗效相仿。西酞普兰不良反应小。结论西酞普兰治疗难治性强迫症疗效与氯米帕明相当,安全性高,不良反应轻微,依从性好。西酞普兰适用于难治性强迫症。
Objective To compare the efficacy and side effects of citalopram and clomipramine in the treatment of patients with refractory obsessive-compulsive disorder（OCD）.Methods Sixty-four patients were randomly divided into two groups treated with citalopram and clomipramine respectively for 8 weeks.The efficacy and side effects were monitored with clinical evaluation,Yale-Brown obsessive compulsive scale（Y-BOCS） and treatment emergent symptoms scale（TESS）.Results The scores of Y-BOCS decreased more markedly after the treatment than those before the treatment in two groups（P0.05）;There were no significant differences after the treatment in 4th,6th,8th weekend（P0.05）.Citalopram and clomipramine were effective to refractory OCD,but citalopram had less side effects.Conclusion Although citalopram has similar efficacy with clomipramine in the treatment of the patients with refractory obsessive-compulsive disorder（OCD）,but the former is safer with slighter side reaction and better compliance.Citalopram is a more suitable drug for patients with refractory obsessive-compulsive disorder（OCD）.
出处
《实用心脑肺血管病杂志》
2010年第5期588-589,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
西酞普兰
氯米帕明
难治性强迫症
Citalopram
Clomipramine
Refractory obsessive-compulsive disorder
