摘要
恶性肿瘤的侵袭转移能力是肿瘤治疗的一大难点。近些年来,小分子RNA(miRNA)的出现为研究肿瘤的发生及侵袭转移机制提供了新的思路和途径,微小RNA(miRNA)是一类内源性、保守、稳定的非编码短单链RNA,在转录后水平调节靶基因表达。miRNA在机体发育,细胞增殖、凋亡及肿瘤发生发展等生理和病理过程中发挥重要作用。miR-10b作为微小RNA家族中的一员,在肝癌、乳腺癌、胰腺癌、胶质瘤、垂体瘤、急性髓性白血病等肿瘤组织中都有异常表达,并且与肿瘤的侵袭性和远处转移有密切关系。
The invasion and metastasis of malignant tumour was a major difficulty to cancer treatment.In recent years,the emergence of small-molecule RNA（miRNA）will provide new ideas and approaches to study tumor invasion and metastasis,micro RNA（miRNA）was a kind of endogenous,conservative,stable short single-stranded non-coding RNA,to regulate the expression of target genes after transcription.The miRNA played an important role in the physiological and pathological processes such as body development,cell proliferation,apoptosis and tumor development,miR-10b as a member of the small family RNA has abnormal expression in the liver,breast,pancreatic,glioma,pituitary tumor,acute myeloid leukemia,has a close relation to tumor invasiveness and distant metastasis.
出处
《医学综述》
2010年第10期1476-1479,共4页
Medical Recapitulate
基金
国家自然科学基金(30672165
30872657)
江苏省333工程重点人才项目(0508RS08)
江苏省医学重点人才项目(RC2007061)
