摘要
目的探讨重型颅脑损伤病人早期实施肠内营养对免疫功能及并发症的影响。方法对168例重型颅脑损伤病人(GCS≤8分)半随机分为肠内营养组(EN组)和肠外营养组(PN组),每组84例。用免疫组化法测定两组患者在入院后10d血清中IgG、IgA、IgM及IgE含量及T淋巴细胞亚群CD4+、CD8+、CD4+/CD8+值,对比两组的免疫功能变化。结果重型颅脑损伤后病人免疫功能明显下降,而EN组患者血清中的IgG、IgA、IgM显著高于PN组(P<0.05);CD4+水平及CD4+/CD8+比值明显高于PN组(P<0.05);IgE明显低于PN组(P<0.05)。EN组的并发症发生率明显低于PN组(P<0.05)。结论重型颅脑损伤病人可导致机体免疫功能下降,早期肠内营养支持可提高人体免疫功能,减少并发症的发生。
Objective To investigate the changes in the immune function and complications after early enternal nutrition in patients with severe brain injury.Methods One hundred and sixty-eight patients with severe brain injury（GCS≤8 point）were randomly divided into both the early enternal nutrition（EN）groups（84 cases）,in which EN was performed by duodenal catheter,and parenteral nutrition（PN）group（84 cases）.The serum levels of IgG,IgA,IgM,IgE and the T lymphocyte subsets CD4＋,CD8 ＋ and ratio of CD4＋ toC D8＋ were detected by immunohistochemical method 10 days after the admission to hospital.Results The serum levels of IgG,IgA,IgM,C D4 ＋ and ratio of CD4 ＋ /CD8 ＋ were significantly higher in EN group than those in PN group（P0.05）.The serum levels of IgE in EN group was significantly lower than that in PN group（P0.05）,in which the complications were more than in EN group（P0.05）.Conclusions The immunological function of patient with severe brain injury is decreased.Early EN by duodenal catheter may enhance the immune function and decrease complications in the patients with severe brain injury.
出处
《中国临床神经外科杂志》
2010年第5期283-285,共3页
Chinese Journal of Clinical Neurosurgery
关键词
重型颅脑损伤
肠内营养
免疫功能
T淋巴细胞亚群
免疫组化法
Severe brain injury
Enternal nutrition
Immunological function
T lymphocyte subsets
Immunohistochemical method
