辛伐他汀对COPD急性加重期患者诱导痰血管内皮生长因子水平和肺功能的影响被引量：15

Simvastatin Improves Pulmonary Function and Vascular Endothelial Growth Factor Level in Induced Sputum of Patients with COPD Exacerbation

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摘要目的探讨辛伐他汀对COPD急性加重期(AECOPD)患者诱导痰血管内皮生长因子(VEGF)水平和肺功能的影响。方法选择2007年5月至2008年11月住院的58例AECOPD患者,随机分常规组(30例)和他汀组(28例)。常规组按照诊疗常规予以AECOPD常规治疗,他汀组在常规治疗基础上加用辛伐他汀治疗。两组均于入院第1d和治疗1周后行肺功能检查,并收集诱导痰,采用ELIAS方法测定血清和诱导痰上清VEGF的含量。结果治疗前两组肺功能(FEV1%pred和FEV1/FVC)、诱导痰VEGF水平无显著差异(P>0.05)。常规组治疗1周后与治疗前比各项指标无明显变化(P>0.05)。他汀组治疗1周后FEV1%pred和FEV1/FVC均较治疗前显著升高(P均<0.01),且显著高于常规组(P均<0.01);诱导痰VEGF的水平较治疗前及常规组显著升高(P均<0.05),但血清VEGF的水平两组及两组治疗前后无显著差异(P均<0.05)。治疗1周后诱导痰VEGF水平与FEV1%pred和FEV1/FVC呈正相关(r=0.430,P<0.05;r=0.388,P<0.05)。结论辛伐他汀可改善AECOPD患者肺功能,并提高AECOPD患者诱导痰VEGF的水平。肺功能的改善可能与肺内VEGF水平的恢复有关。 Objective To investigate the effects of simvastatin on pulmonary function and vascular endothelial growth factor （VEGF） levels in induced sputum of patients with COPD exacerbation（AECOPD）.Methods Thirty-eight patients with AECOPD were divided into two groups randomly,ie.a routine medical treatment（RT） group（n=30） and a routine ＋ statin medical treatment（RST） group（n=28）.The VEGF levels in serum and induced sputum were detected by ELISA on the first day and after a week treatment in hospital,respectively.Meanwhile,the pulmonary function measurements were performed.Results There were no significant differences in the pulmonary function （FEV1%pred and FEV1/FVC） and VEGF levels in induced sputum between the two groups before treatment（P0.05）.The RT group showed no significant changes in any parameters before and after a week treatment（P0.05）.FEV1%pread,FEV1/FVC and VEGF levels in induced sputum in the RST group after a week treatment significantly increased compared with those before treatment and the RT group（P0.01,P0.01,P0.05）.But There were no significant differences in serum VEGF levels between the two groups before and after a week treatment.The VEGF levels in induced sputum were positively correlated to FEV1%pread and FEV1/FVC after a week treatment（r=0.430,P0.05;r=0.388,P0.05）.Conclusions Simvastatin may reduce the decline in pulmonary function and decrease the levels of VEGF in induced sputum of patients with AECOPD.Improvement in pulmonary function may be related to down-expression of lung VEGF.

作者夏书月康健何巍许晓阳何晓琳王实

机构地区沈阳医学院奉天医院呼吸内科中国医科大学呼吸疾病研究所

出处《中国呼吸与危重监护杂志》 CAS 2010年第3期295-297,共3页 Chinese Journal of Respiratory and Critical Care Medicine

基金沈阳医学院科研课题(编号:20061001)

关键词慢性阻塞性肺疾病急性加重诱导痰血管内皮生长因子辛伐他汀 Chronic obstructive pulmonary disease Acute exacerbation Sputum induction Vascular endothelial growth factor Simvastatin

分类号 R563.9 [医药卫生—呼吸系统]

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参考文献12

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