摘要
研究毛竹叶多糖的降血脂、肝脂及促进肝损伤修复的作用。以正常小鼠作空白对照,将高脂血症脂肪肝模型小鼠分为高脂模型组、毛竹叶多糖低、中、高剂量组和血脂康阳性药物对照组,进行不同灌胃处理,测定小鼠血脂、血清谷丙转氨酶(ALT)、肝粗脂肪含量、肝指数及肝组织细胞形态变化。结果表明:毛竹叶多糖可显著降低小鼠血清总胆固醇(TCHO)、甘油三酯(TG)、低密度脂蛋白(LDL);对血清高密度脂蛋白(HDL)影响不明显;可显著降低肝粗脂肪含量,改善小鼠的肝功能。
In order to investigate the functions of polysaccharide from moso bamboo leaves（PMBL） for decreasing blood lipid and liver lipid and promoting the recovery of damaged liver,the mice model with hyperlipidemia was established through the feeding of high-fat food to evaluate the effect of PMBL on lipid metabolism of mice.Totally 50 mice were divided into 5 groups designated as hyperlipidemia model group,PMBL groups at low,middle and high dosages,and positive control group.Blood lipid,serum ALT,crude fat content in liver,liver index and morphological change of liver tissues were evaluated.Results indicated PMBL could result in a significant reduction of total cholesterol,triglyceride and low-density lipoprotein in serum;however,no significant effect on high-density lipoprotein was observed.In addition,PMBL could decrease crude fat content in liver,and improve the hepatic function of mice.In a word,PMBL exhibited anti-lipidemic activity and lipid-reducing effect in liver to enhance the repairing of damaged liver in mice with hyperlipidemia at the condition of optimal dosage.
出处
《食品科学》
EI
CAS
CSCD
北大核心
2010年第9期259-262,共4页
Food Science
基金
教育部"长江学者和创新团队发展计划"项目(IRT0540)
关键词
毛竹叶多糖
高血脂
脂肪肝
降血脂
肝功能
polysaccharide from moso bamboo leaves
hyperlipemia
fatty liver
blood-lipid lowering
hepatic function
