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NF-κB信号通路和脑出血后的继发性脑损伤 被引量：10

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摘要 核因子Kappa B(Nuclear factor Kappa B,NF-κB)是一种广泛存在于哺乳动物细胞中的转录因子,近年来越来越多的证据表明,它与脑出血后的继发性脑损伤的关系密切。本文从NF-κB的生物学特性出发阐述了NF-κB信号通路在脑出血后继发性脑损伤中的作用及其机制,包括:促进炎性因子IL-1β、ICAM-1等的表达,引发和加重炎症反应;上调MMP-9的表达,破坏血脑屏障,加重血管源性脑水肿;促进细胞凋亡的发生。
作者 叶欣 万曙 詹仁雅
机构地区 浙江大学医学院附属第一医院神经外科
出处 《国际神经病学神经外科学杂志》 2010年第2期171-175,共5页 Journal of International Neurology and Neurosurgery
基金 浙江省自然科学基金(Y2080402) 浙江省医药卫生科学基金(2006A045) 浙江省钱江人才计划项目(2009R10074)
关键词 脑出血 继发性脑损伤 NF-ΚB IκBs
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献21

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二级参考文献25

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共引文献4

同被引文献101

引证文献10

二级引证文献27

国际神经病学神经外科学杂志
2010年 第2期

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