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丙硫氧嘧啶导致的抗中性粒细胞胞浆抗体相关性血管炎的临床研究 被引量：4

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摘要 目的提高临床对丙硫氧嘧啶（PTU）引起抗中性粒细胞胞浆抗体（ANCA）相关性血管炎的认识。方法分析近年诊治的6例刖引起ANCA相关小血管炎患者的临床表现、实验室检查、病理检查、治疗及随访情况，结合文献及联系显微镜下多血管炎（MPA）的临床特点进行分析。结果6例服用PITU的患者出现肺、肾、皮肤及消化道等多脏器受累，其中5例抗MPO—ANCA阳性，1例抗PR3-ANCA阳性。停用PTU，使用激素或联合免疫抑制剂治疗后病情好转，ANCA转阴。结论刑可引起ANCA相关小血管炎，尽管ANCA滴度高，但致病性较弱，及时停用PITU及给予相应治疗，预后较好。
作者 徐益明 金美玲
机构地区 复旦大学附属中山医院呼吸内科
出处 《临床内科杂志》 CAS 2010年第5期343-345,共3页 Journal of Clinical Internal Medicine
关键词 丙硫氧嘧啶 抗中性粒细胞胞浆抗体 血管炎
分类号 R593.9 [医药卫生—内科学]
  • 相关文献

参考文献5

二级参考文献31

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共引文献94

同被引文献14

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引证文献4

二级引证文献7

临床内科杂志
2010年 第5期

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