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NALPs及其信号调节通路在痛风炎症反应中的作用 被引量：3

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摘要 NALPs（ NACHT-LRR-PYD-containing proteins ）是一个近年在炎症反应中m现的胞质蛋白家族，作为NOD样受体（ NOD-like receptors, NLRs ）家族中的业族之一，同Toll样受体（Toll-like receptors,TLRs ）一样，是固有免疫系统对病原体的一类重要感受器，广泛参与病原体上的病原相关分子模式（pathogen-asssociated molecular patterns, PAMPs ）的识别，
作者 杨其彬 周京国
机构地区 川北陕学院附属医院风湿免疫研究所
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2010年第5期347-349,共3页 Chinese Journal of Rheumatology
基金 四川省卫生厅科研基金（070289）
关键词 炎症反应 信号调节 TOLL样受体 病原相关分子模式 痛风 通路 PAMPS 胞质蛋白
分类号 R589.7 [医药卫生—内分泌]
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参考文献21

  • 1Tschopp J,Martinon F,Burns K.NALPs:a novel protein family involved in inflammation.Nat Rev Mol Cell Biol,2003,4:95-104.
  • 2Rosenstiel P,Till A,Schreiber S.NOD-like receptors and human disease.Microbes Infect,2007,9:648-657.
  • 3Pétrilli V,Martinon F.The inflammasome,autoinflammatory diseases and gout.Joint Bone Spine,2007,74:571-576.
  • 4Kummer JA,Bruekhisen R.Everett H,et al.Inflammasome components NALPI and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response.J Histochem Cytochem,2007,55:443-452.
  • 5Delbtidge LM,O' Riordan MX.Innate recognition of intraeellular bacteria.Curr Opiu Immunol,2007,19:10-16.
  • 6Martinon F,Tschopp J.Inflammatory caspases and inflammasomes:master switches of inflammation.Cell Death Differ,2007,14:10-22.
  • 7Mayor A,Martinon F,De Smedt T,et al.A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses.Nat Immunol,2007,8:497-503.
  • 8O'Connor W Jr,Harton JA,Zhu X,et al.Cutting edge:CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties.J Immunol,2003,171:6329-6333.
  • 9Lamkanfi M,Kahfi M,Saelens X,et al.Caspase-1 activates nuclear factor of the kappa-enhancer in B cells independently of its enzymatic activity.J Biol Chem,2004,279:24785-24793.
  • 10Shi Y,Evans JE,Rock KL.Molecular identification of a danger signal that alerts the immune system to dying cells.Nature,2003,425:516-521.

同被引文献80

  • 1黄火高,孙运峰,胡明,袁广胜,王琼,刘永学.大鼠急性痛风性关节炎模型的建立及特点[J].军事医学科学院院刊,2005,29(6):538-542. 被引量：60
  • 2熊湘明,田凤石,姜霞.二妙散加减方对实验性高尿酸血症肾损害的保护作用[J].天津医科大学学报,2007,13(1):90-92. 被引量：15
  • 3Martinon F, Mayor A, Tschopp J. The inflammasomes : guardians of the body. Annu Rev Immunol,2009 ,27 :229 -265.
  • 4Kawai T,Akira S. The roles of TLRs, RLRs and NLRs in patho- gen recognition. Int Immunol,2009,21 (4) : 317 -337.
  • 5Meylan E,Tschopp J, Karin M. Intracellular pattern recognition re- ceptors in the host response. Nature,2006,442 (7098) :39 - 44.
  • 6Franchi L,Eigenbrod T, Munoz - Planillo R, et al. The inflamma- some : a caspase - 1 - activation platform that regulates immune re- sponses and disease pathogenesis. Nat Immunol,2009,10(3) :241 - 247.
  • 7Petrilli V, Dostert C, Muruve DA, ct al. The inflammasome : a dan- ger sensing complex triggering innate immunity. Curr Opin Immu- nol,2007,19(6) : 615 -622.
  • 8Martinon F,Tschopp J. Inflammatory caspases and inflammasomes: master switches of inflammation. Cell Death Differ,2007,14 ( 1 ) : 10 - 22.
  • 9McCall SH, Sahraei M, Young AB, et al. Osteoblasts express NL- RP3, a nucleotide - binding domain and leucine - rich repeat re- gion containing receptor implicated in bacterially induced cell death. J Bone Miner Res,2008,23 (1) :30 -40.
  • 10Kummer JA,Broekhuizen R, Everett H, et al. Inflammasome com- ponents NALP 1 and 3 show distinct but separate expression pro- files in human tissues suggesting a site - specific role in the inflam- matory response. J Histochem Cytochem, 2007,55 ( 5 ) : 443 - 452.

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中华风湿病学杂志
2010年 第5期

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