摘要
目的探讨血清晚期糖基化终产物(AGEs)水平在冠心病(CAD)合并糖尿病(DM)患者中的意义。方法诊断明确的CAD合并DM患者82例,根据冠状动脉造影结果分为单支病变组、双支病变组及3支病变组,分别测定血清AGEs、空腹血糖(FPG)、血脂,计算体质量指数(BMI),对3组间AGEs、FPG、血脂、BMI进行比较。结果AGEs水平随冠状动脉病变支数增加而增高,单支病变组(35.86±11.28)ng/L,双支病变组(43.52±17.29)ng/L,3支病变组(62.09±14.23)ng/L,差异有统计学意义(P<0.05);Spearman相关分析显示,AGEs与总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、FPG均呈正相关(P<0.05);多元逐步线性回归分析显示,LDL-C、FPG与AGEs独立相关。结论AGEs促进DM患者冠状动脉粥样硬化的发展,控制FPG及LDL-C可能延缓此作用。
Objective To investigate the value of advanced glycosylation end products（AGEs） level in patients with coronary artery disease（CAD） complicated diabetic disease（DM）. Methods Totally 82 patients with CAD and DM who underwent selective coronary angiography（CAG） were divided into single-,double- and triple-vessel disease group according to the number of vessels with significant stenosis. AGEs, FPG, serum lipids were measured, BMI was calculated. AGEs, fasting plasma glucose （FPG）, serum lipids were compared among groups. Results There were significant differences in AGEs level among different vessel disease groups, the single-vessel disease group （35.86 ± 11.28） ng/L, the double-vessel disease group （43.52 ±17.29） ng/L and the triple-vessel disease group （62.09±14.23） ng/L（ P 〈0.05）. Spearman correlations showed that AGEs level was positively and significantly correlated with TC,LDL-C,FPG. Multivariate linear regression model showed that LDL-C and FPG were independent factors for AGEs. Conclusion AGEs accelerated the development of atherosclerosis in patients with CAD and DM,controlling the level of LDL-C and FPG may delay the progress.
出处
《临床荟萃》
CAS
2010年第11期924-926,共3页
Clinical Focus
关键词
冠状动脉疾病
糖基化终产物
高级
血糖
胆固醇
LDL
coronary disease
glycosylation end products, advanced
blood glucose
cholestrol, LDL
