摘要
目的研究河北省新确认的不同亚型HIV-1感染者的CD4+/CD8+T淋巴细胞水平,探讨不同亚型人群的CD4+/CD8+T淋巴细胞水平有无差异。方法选取2008年1~12月新确认的HIV-1感染者55例,利用分子生物学方法进行分型后,对不同亚型人群的CD4+/CD8+检测数据进行分析统计。结果在55例已确定亚型的HIV-1感染者中,B亚型与CRF01-AE亚型、CRF07-BC亚型的CD4+T淋巴细胞水平之间差异有统计学意义(P<0.05)。CRF01-AE亚型、CRF07-BC亚型两者的CD4+T淋巴细胞水平之间差异无统计学意义(P>0.05)。但是B亚型与CRF01-AE亚型、CRF07-BC亚型三者之间的CD8+T淋巴细胞水平差异无统计学意义(P>0.05)。结论在新确认的3种不同亚型HIV-1感染者中,CD4+T淋巴细胞水平是不同的,以B亚型感染者为最低;三者之间的CD8+T淋巴细胞水平差异无统计学意义,推测可能与HIV-1感染途径和感染时间有关。
Objective To study the CD4＋/CD8＋ cells count of HIV-1 de-novo identified individuals for different subtypes in Hebei Province and detect the CD4＋/CD8＋ T lymphocyte cell counts between different subtypes. Methods The subtypes of 55 samples from de-novo identified individuals who had been identified in 2008 Jan-Dec were determined by molecular methods and the CD4＋/CD8＋ counts were detected by flow cytometry. Results There were significant difference in CD4＋ lymphocyte cells count between B subtypes and CRF01-AE subtypes （ P 〈 0.05）, CRF07-BC subtypes（ P d0.05）. There was no significant difference in CRF01-AE subtypes and CRF07-BC subtypes. However,no significant difference existed in CD8＋ lymphocyte cells count between B subtypes, CRF01-AE subtypes and CRF07-BC subtypes. Conclusion CD4＋ T lymphocytes counts of first identified are very low in B subtypes and higher in CRFO1-AE subtypes and CRFO7-BC subtypes. There are no significant difference in CD8＋ lymphocyte cells count of I3 subtypes,CRF01-AE subtypes and CRF07-BC subtypes,which may relate with infected routes and infected time.
出处
《临床荟萃》
CAS
2010年第12期1021-1023,共3页
Clinical Focus
基金
河北省2008年医学科学研究重点课题计划(08042)
