摘要
目的 探讨不同代偿功能的肝硬化患者血清血小板生成素（TPO）水平与血小板（PLT）的关系.方法 将40例肝硬化患者按肝功能代偿与否分为代偿组（n=15）和失代偿组（n=25）,同时选取同期健康体检者17例作为对照组.用ELISA法测定3组患者血清TPO水平.结果 对照组、肝硬化肝功能代偿组和失代偿组的血清TPO水平分别为（136.24±68.56）pg·ml^-1、（124.34±41.31）pg·ml^-1和（59.05±52.77）pg·ml^-1;肝硬化肝功能失代偿组的血清TPO水平较对照组明显降低（P〈0.01）;肝硬化患者的血清TPO水平与外周PLT计数之间无明显相关性,而与血清白蛋白水平呈显著正相关（r=0.86,P〈0.01）,与血清总胆红素水平呈负相关（r=-0.49,P〈0.05）.结论 肝细胞产生TPO不足可能是肝硬化引发PLT减少的主要原因,血清TPO水平是评价肝硬化患者肝功能的有用指标.
Objective To investigate the relationship between serum thrombopoietin （TPO） levels and thrombocytopenia in patients with liver cirrhosis. Methods Serum TPO levels in patients with liver cirrhosis （compensated, decompensated and control groups） were detected by ELISA. Results The serum TPO levels in control, compensated and decompensated groups were （136.24 ±68.56）pg ·ml^-1, （124.34±41.31） pg ·ml^-1 and （59.05 ±52.77） pg·ml^-1 respectively. The TPQ level in the decompensated group was significantly lower than that of control group （P〈0.001）. In patients with liver cirrhosis, the serum TPO level was positively correlated with serum concentration of album （r=0.86,P〈0.001） and negatively correlated with serum concentration of total bilirubin （r=0.49,P〈0.05）. Conclusion Insufficient of TPO in liver might be the main cause of thrombocytopenia in the patients with liver cirrhosis, which may be used as an indicator for liver function in cirrhotic patients.
出处
《浙江医学》
CAS
2010年第5期672-673,676,共3页
Zhejiang Medical Journal
