摘要
目的:观察妊娠高血压综合征患者血液血管内皮生长因子(VEGF)、fms-样酪氨酸激-酶4flt-4)和胎盘一氧化氮(NO)的表达及其临床意义。方法:选择妊高征患者35例为妊高组;选择同期正常晚期妊娠妇女36例为对照组。采用酶联免疫吸附法测定各组孕妇血清VEGF及其受体flt-4的含量,采用硝酸还原法测定胎盘组织NO浓度。结果:妊高组患者血清VEGF及其受体flt-4水平、胎盘组织NO含量与对照组相比,明显降低(P<0.05);妊高组患者血清VEGF水平与胎盘组织NO含量呈正相关(r=0.723,P<0.05),flt-4的水平与胎盘组织NO含量呈正相关(r=0.61,P<0.05)。结论:血清VEGF及其受体flt-4在妊娠高血压综合征患者发病中有重要作用,它们可能通过影响NO的合成进一步在妊高征发病中发挥作用。
Objective：To observe the expression of Vascular endothelial growth factor D（VEGF-D） and fms-like tyrosine kinase-Enzyme 4（flt-4）and nitric oxide（NO） in pregnancyinduced hypertension patients and its clinical significance.Methods：35 patients with pregnancy-induced hypertension for the PIH group;choose the same period 36 cases of normal late pregnant women as control group.Enzyme-linked immunosorbent assay was used to detect the content of maternal serum VEGF and its receptor flt-4,and nitrate reduction measured was used to measure the NO concentration in placental tissue of each group.Results：The levels of serum VEGF and its receptor flt-4 levels,and NO content in placental tissues of PIH group were significantly lower than that of control group（P0.05）.In PIH group,the serum VEGF levels were positively related with NO levels in placental tissue（r= 0.723,P0.05）,and so were the flt-4 levels（r=0.61,P 0.05）.Conclusion：Serum VEGF and its receptor flt-4 play an important role in the pathogenesis of pregnancy induced hypertension.They may influence the NO synthesis and further influence the pathogenesis of pregnancy induced hypertension.
出处
《现代生物医学进展》
CAS
2010年第9期1713-1715,共3页
Progress in Modern Biomedicine
关键词
妊娠高血压
血管内皮生长因子D
fms-样酪氨酸激-酶4
一氧化氮
Pregnancy-induced hypertension
Vascular endothelial growth factor D
fms-like tyrosine kinase-enzyme 4
Nitric oxide
