摘要
目的:探讨3.0T磁共振扩散张量成像(DTI)对脑梗死的诊断价值。方法:对75例不同时期脑梗死患者进行MRI常规检查、扩散加权成像(DWI)及DTI检查,重建平均扩散系数(DCavg)图及部分各向异性(FA)图。以T2WI与DWI图像为参照,测定各期脑梗死灶及对侧正常脑组织的平均DCavg值、平均FA值,并进行统计学处理。结果:与对侧正常脑组织相比,脑梗死平均DCavg值在超急性期及急性期显著减低(P<0.01),随着时间延长呈逐渐恢复升高的变化趋势;脑梗死平均FA值在超急性期无一致性变化,与对侧正常脑组织相比差异无统计学意义(P>0.05),可轻度升高或轻度降低,随着病程进展呈不可恢复持续减低规律。结论:联合DCavg值与FA值可对脑梗死进行更精确的临床分期,有助于及时准确了解脑梗死的病理生理改变,为临床治疗及预后判断提供依据。
Objective：To evaluate the value of diffusion tensor imaging（DTI） in the diagnosis of cerebral infarction with 3.0T MR scanner.Methods：Seventy-five patients with different stages of cerebral infarction underwent conventional MRI,diffusion weighted imaging（DWI）,and DTI.The average diffusion coefficient（DCavg） images and part of the fractional anisotropy（FA） images were reconstructed.Using T2WI and DWI maps as references,the values of DCavg and mean FA in the infarct regions of various stages and contralateral normal brain regions were measured.Statistical analysis was performed.Results：Compared with the contralateral normal brain tissues,the values of DCavg decrease significantly in superacute and acute stages of cerebral infarction（P〈0.01）.With the time of cerebral infarction prolonged,the DCavg values showed the tendency of gradual increasing.No consistent change was showed in the mean FA values of superacute stage as compared with the contralateral brain tissue（P〈0.05）,they could be slightly increased or decreased,then showed a ten-dency of irreversible decreasing as the course of disease progressed.Conclusion：Values of DCavg in combination with FA could be helpful in assessing the stage of cerebral infarction more precisely as well as understanding the patho-physiological changes,and to provide the evidence of treatment guidance and prognosis judging.
出处
《放射学实践》
北大核心
2010年第5期481-484,共4页
Radiologic Practice
关键词
脑梗死
扩散张量成像
磁共振成像
Cerebral infarction
Diffusion tensor imaging
Magnetic resonance imaging
