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非小细胞肺癌中垂体瘤转化基因的表达及临床意义

Association of PTTG Expression with Biological Behaviors of Non-small Cell Lung Cancer
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摘要 目的:研究垂体瘤转化基因在非小细胞肺癌组织、肺良性病变组织和正常支气管黏膜上皮组织中的表达,初步探讨其与非小细胞肺癌发生发展,侵袭转移的关系。方法:(1)用SP免疫组化法检测76例临床石蜡组织标本(44例非小细胞肺癌、20例肺良性病变组织和12例正常支气管黏膜上皮组织)中的PTTG蛋白的表达。(2)用RTPCR法分析PTTG mRNA在不同性质肺组织中的表达情况。结果:(1)PTTG蛋白在不同性质肺组织中的表达差别具有明显差异;在TNM分期、淋巴结转移组间差别有统计学意义。(2)PTTG mRNA在不同性质肺组织中的表达差别具有明显差异(P<0.001);在TNM分期、淋巴结转移组间差别有统计学意义。结论:细胞肺癌的发生发展及转移有关。 Objective:To investigate the association between PTTG expression and biological behaviors of human non-small cell lung cancer(NSCLC).Methods:SP immunohistochemistry was used to detect the expression of PTTG in 76 cases of paraffin-embedded specimens(including 44 surgical specimens from NSCLC patients.20 pneumonic benign lesion and 19 normal bronchial epithelium).Real-time RT-PCR was performed to detect PTTGm RNA expression in 44 cases of fresh carcinoma and corresponding adjacent normal mucosa specimens.Results:The expression levels of PTTG was significantly different between normal mucosa and adenoma tissues.There were statistical relationships between their expressions and TNM stage,lymphnode metastasis.Conclusion:PTTG may play an important role in carcinogenesis、development and metastasis of human non-small cell lung cancer.
出处 《华西医学》 CAS 2009年第11期2938-2940,共3页 West China Medical Journal
关键词 非小细胞肺癌 垂体瘤转化基因 逆转录聚合酶链反应 免疫组织化学 non-small cell lung cancer PTTG RT-PCR IHC
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参考文献4

  • 1PEI L, MELMED S. Isolation and characterization of a pituiyary tumor-transforming gene (PTTG)[J]. Mol Endocrinol, 1997, 11 (4) :433-441.
  • 2ZHANG X, HORWITZ G A, HEANEY A P, et al. Pituitary tumor transforming gene (PTTG) expression in Pituitary adenomas[J]. Clin Endocrinol Metab, 1999,84 (2) : 761 - 767.
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  • 4SOLBACH C, ROLLER M, FELLBAUM C, et al. PTTG mRNA expressionin primary breast cancer [J]. Breast, 2004,13 ( 1 ) : 80.

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