摘要
病毒是专性细胞内寄生物,其复制很大程度上依赖于宿主细胞。病毒与宿主细胞的相互作用对二者均具有重要意义。微小RNA(miRNA)是在多细胞真核生物中新近发现的一类重要的基因表达转录后调控分子,其作为关键的效应分子,在复杂的病毒与宿主相互作用网络中发挥重要作用。病毒和宿主细胞均可编码miRNA。病毒编码的miRNA能够直接改变宿主环境,包括免疫系统分子构成;而细胞编码的miRNA能够直接影响病毒的复制周期。本文主要对miRNA调控病毒与宿主细胞相互作用的最新进展作一综述。
Viruses are obligate intracellular parasites whose replication depends on their hosts.This interplay has important consequences,both for the virus and the host.MicroRNAs（miRNAs）have recently emerged as key posttranscriptional regulators of gene expression in multicellular eukaryotes.Recent reports also throw light into the role of microRNAs as critical effectors in the intricate host-pathogen interaction networks.Evidence suggests that both virus and hosts encode microRNAs.Viral miRNAs can directly alter host physiology,including components of the immune system,and host miRNAs can directly alter the virus life cycle.This paper summarizes the latest news on host-virus interactions through viral miRNAs or cellular miRNAs.
出处
《中国生物制品学杂志》
CAS
CSCD
2010年第5期549-553,共5页
Chinese Journal of Biologicals
