摘要
目的观察急性有机磷农药中毒（AOPP）患者血液毒物持续时间及与病情判断、治疗、预后的关系。方法对2008年7月至2009年6月本院急诊科AOPP病例运用气相色谱法进行血液毒物浓度（以下简称＂血药浓度＂）监测,观察血液毒物存在时间及血药浓度高低、血液毒物持续存在时间与血液胆碱酯酶（ChE）、氯磷定应用、住院时间的关系。结果 AOPP患者血液毒物持续存在时间多在3-7d,较传统看法明显延长;初始血药浓度较高和血液毒物持续存在时间较长者ChE恢复慢,氯磷定应用时间长、剂量大,病情重、住院时间长。结论血药浓度监测对AOPP的病情判断、指导治疗、改善预后有重要意义。
Objective To study how to diagnose, treat and evaluate the patient with acute organophosphorus pesticides poisoning （AOPP）by testing the concentration of AOPP in serum. Methods We collected all the AOPP poisoned patients from 2008 July to 2009 June. The concentration of AOPP in serum were tested by vapor phase chromatography in each patient to study the relationship between the level of ChE in serum, the dose of pralidoxime chloride, stage of hospitalization and the concentration of AOPP in serum. Results The time which AOPP could be tested in serum was from 3 to 7 days, which was significantly longer than the traditional view. If the initial concentration of AOPP was higher and the time which AOPP could be tested in serum was longer, the patients were more severely, the level of ChE in serum recovered slowly, the patients needed high doses of pralidoxime chloride and longer time of therapy, stage of hospitalization was longer. Conclusion There is an important role in judging the severity, directing the treatment and improving the survival rate of AOPP poisoned patients by testing the concentration of AOPP in serum.
出处
《医学研究与教育》
CAS
2010年第3期16-17,29,共3页
Medical Research and Education
关键词
有机磷农药
血药浓度
监测
acute organophosphorus pesticides poisoning
the concentration in serum
test
