摘要
目的采用新型的连续加碱法制备水溶性羧甲基壳聚糖,并对合成工艺进行优化。方法以壳聚糖、氯乙酸为原料,苄基三乙基氯化铵(TEBA)为催化剂,采用连续加碱法制备羧甲基壳聚糖,考察催化剂使用量、反应温度、反应时间和投料比对羧甲基壳聚糖取代度(DS)和溶解性的影响。结果最佳反应条件为:以6%的苄基三乙基氯化铵作催化剂,m(壳聚糖):m(氯乙酸)为1:5,反应温度90℃,反应时间5h时,羧甲基壳聚糖的取代度(DS)和溶解率分别达到1.35和99.10%。结论本法制备的羧甲基壳聚糖具有优越的水溶性能,是一种制备羧甲基壳聚糖的有效方法 。
Objective To prepare water soluble carboxymethyl chitosan by a new kind of continuous alkali-feeding method,and to optimize its synthetic conditions.Methods With chitosan and chloroacetate as the reactants and triethyl-benzylammonium （TEBA） as catalyst,carboxymethyl chitosan（CMC） was synthesized by continuous alkali-feeding method.The effects of carboxymethylation conditions on the degree of substitution（DS） and solubility of CMC were studied.Results The optimum conditions were as follows：6% triethylbenzylammonium （TEBA） as catalyst,reaction temperature was 90℃,reaction time was 5 h and weight ratio of chitosan to chloroacetic acid was 1：5,the substitution （DS） and the rate of solubility reached 1.35 and 99.10%,respectively.Conclusion The product has superior water-soluble property,and the continuous alkali-feeding method is for the synthesization of CMC.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2010年第5期1187-1189,共3页
Lishizhen Medicine and Materia Medica Research
基金
山东省自然科学重点基金资助项目(No.Y2007C135)
山东省高等学校科技计划(No.J09LF76)
关键词
羧甲基壳聚糖
连续加碱法
絮凝剂
氯乙酸
Carboxymethyl chitosan （CMC）
Continuous alkali-feeding method
Flocculant
Chloroethanic acid
