摘要
目的探讨卡托普利在慢性缺氧性肺动脉高压致肺心病中的作用及其影响机制。方法50例肺心病急性加重期患者分为对照组（25例）和卡托普利组（25例），对照组采用常规治疗，卡托普利组采用常规治疗加卡托普利。彩色多普勒超声测量两组治疗前后的肺动脉压变化；同时检测正常组与两治疗组治疗前后血清SOD、MDA、NO含量变化。结果肺心病患者治疗前血清SOD、NO水平明显低于正常组（P〈0．05），MDA显著高于正常组（P〈0．05）。治疗后卡托普利组和对照组血清SOD明显升高（P〈0．05），MDA明显降低（P〈0．05）；治疗后卡托普利组血清SOD水平显著高于对照组（P〈0．05），血清MDA显著低于对照组（P〈0．05）。治疗后卡托普利组血清NO明显升高（P〈0。05），对照组血清NO轻度升高，但无统计学意义（P〉0，05）。肺心痛患者治疗前肺动脉压显著高于正常组（P〈0．05），治疗后卡托普利组和对照组肺动脉压明显降低（P〈0．05）。结论卡托普利干预提高肺心病患者血清SOD、NO含量，降低血清MDA水平和肺动脉高压。
Objective The purpose of this study was to investigate the effect of captopril on serum SOD, MDA ,NO level in patients with cor pulmonale and the role of captopril in treatment of cor pulmonale. Methods 50 patients with cot pulmonale were randomly divided into control group（25 cases）and captopril group（25 cases）, control group were treated with antibiotics and oxygen, and captopril group were treated with antibiotics ,oxygen and captopril. The plasma SOD, MDA ,NO levels,pulmonary artery pressure（PAP） and cardiac index（CI） of 60 patients with cor pulmonale and 30 normal population were measured before and after treatment. Results The results showed that the plasma SOD, NO level and CI of patients with cor pulmonale were significantly lower than the normal group （P 〈 0. 05 ） , while the plasma MDA level and PAP of patients with cot pulmonale were significantly higher than the normal group （ P 〈 0. 05 ）. After treatment, the the plasma MDA level and PAP declined significantly in both control and captopril groups of patients（P 〈0. 05） ,while the plasma SOD level increased significantly in both con- trol and captopril groups of patients（P 〈 0. 05 ） ;and the MDA level in patients treated with captopril was lower than that in patients of control group （P 〈 0.05 ）, the plasma SOD level in patients treated with captopril was higher than that in patients of control group（ P 〈 0.05 ） ;the plasma NO level in patients treated with captopril were significantly higher than before treatment,but the NO level in control groups of patients was not statistically significant compared with before treatment （P 〉 0. 05）. Conclusion captopril can increase the plasma SOD, NO level of patients with eor pulmonale,while decline the plasma MDA level and PAP of them. These suggest that Captopril may improve the outcomes of patients with cor pulmonale through inhibiting oxidative stress and bettering vascular endothelial function.
出处
《中外医学研究》
2010年第10期6-8,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
