摘要
目的通过观察柏子仁皂苷和柏子仁油对小鼠阈下催眠小鼠只数和睡眠时间的影响,考察两柏子仁成分的药效学作用。方法18－22 g昆明种小鼠,按体重、性别均衡随机分为空白对照组,柏子仁皂苷高、中、低剂量组,柏子仁油高、中、低剂量组,共7组。连续给药10 d观察小鼠入睡只数、阈下剂量催眠时间,计算各组小鼠睡眠延长时间。结果柏子仁皂苷高剂量组入睡小鼠只数明显增多,中低剂量不明显。柏子仁油三个剂量组均能不同程度地增加小鼠睡眠只数,其中低剂量组作用明显,高、中剂量组作用相当。柏子仁皂苷高剂量组能明显延长小鼠睡眠时间,中、低剂量组作用相对较弱。柏子仁油低剂量组能明显延长小鼠睡眠时间,高、中剂量组作用相对较弱。结论柏子仁皂苷和柏子仁油均具有镇静催眠作用,柏子仁皂苷作用在一定范围内随剂量增加镇静催眠作用加强,柏子仁油镇静催眠作用在较低浓度时作用增强,在一定范围内又随浓度的增高而药效学作用降低。
Objective To observe the effect of semen platycladi saponins and semen platycladi oil on the numbers of mice and sleep time under subliminal hypnosis and investigate the pharmacodynamic effect of the two components of semen platycladi.Methods Kunming mice of 18~22 g,according to weight and gender balance,were randomized into blank control group,semen platycladi saponins groups of high,middle and low dose;and semen platycladi oil groups of high,middle and low dose,totally 7 groups.After continuous medications for 10 days,the numbers of slept mice,and hypnotic time under threshold were observed;and the prolonged time of sleep was calculated in mice of each group.Results The numbers of slept mice in semen platycladi saponins group of high dose increased apparent,but those in the group of middle and low doses did not increased apparently.The numbers of slept mice in semen platycladi oil groups of three doses all increased to different extents,of which,the increase in the groups of middle and low doses were apparent and the improvement in high-dose and low-dose groups were similar.The sleep time was extended apparently in semen platycladi saponins group of high dose group and that in the groups of middle and low dose was weak relatively.The sleep time was extended apparently in semen platycladi oil group of low dose group and that in the groups of high and middle dose was weak relatively.Conclusion Semen platycladi saponins and semen platycladi oil all have sedative and hypnotic effects.The sedative and hypnotic effect is strengthened with the increase of semen platycladi saponins dose to a certain extent.The sedative and hypnotic effect of semen platycladi oil increases at a lower concentration,but when the concentration increasing,the pharmacodynamic effect of semen platycladi oil deceases.
出处
《世界中西医结合杂志》
2010年第5期394-395,共2页
World Journal of Integrated Traditional and Western Medicine
基金
国家科技部十一五支撑计划(No.2006BAI09B006-05)
关键词
柏子仁皂苷
柏子仁油
药效学
镇静催眠
Semen Platycladi Saponins
Semen Platycladi Oil
Pharmacodynamic
Sedative-Hypnotic
