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NF-κB、PKC与糖尿病及胰岛素的抗炎作用 被引量：12

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作者 肖醉萱 邓德明 孙爱萍
机构地区 长江大学医学院 长江大学附属第一医院荆州市第一人民医院内分泌科
出处 《长江大学学报（自科版）（下旬）》 CAS 2010年第1期J0073-J0076,共4页 Journal of Yangtze University
基金 湖北省卫生厅糖尿病相关基金项目(2007Z1801)
关键词 糖尿病 胰岛素 核因子Kappa-B(NF-κB) 蛋白激酶C(PKC)
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献24

  • 1Brownlee M.Biochemistry and molecular cell biology of diabetic complications[J].Nature,2001,414(6865):813-820.
  • 2Dandona P,Aljada A,ChaudhuriA,et al.Metabolic syndrome:a comprehensive perspective based on interactions between obesity,diabetes,and inflammation[J].Circulation,2005,111(11):1448-1454.
  • 3Larsen L,Storling J,Darville M,et al.Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS1E cells[J].Diabetologia,2005,48(12):2582-2590.
  • 4Sriwijitkamol A,Christ-Roberts C,Berria R,et al.Reduced skeletal muscle inhibitor of kappaB beta content is associated with insulin resistance in subjects with type 2 diabetes:reversal by exercise training[J].Diabetes,2006,55(3):760-767.
  • 5Hofmann MA,Schiekofer S,Isermann B,et al.Peripheral blood mono-nuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB[J].Diabetologia,1999,42(2):222-232.
  • 6狄红杰,赵明,王扬天.糖尿病大鼠视网膜病变核因子-κB表达水平的研究[J].医学研究生学报,2006,19(4):341-343. 被引量：8
  • 7Haslbeck KM,Schleicher E,Bierhaus A,et al.The AGE /RAGE /NF-(kappa) B pathway may contribute to the pathogenesis of polyneuropathy in impaired glucose tolerance (IGT)[J].Exp Clin Endocrinol Diabetes,2005,113(5):288-291.
  • 8Idris I,Gray S,Donnelly R.Protein kinase C activation:isozyme-specific effects on metabolism and cardiovascular complications in diabetes[J].Diabetologia,2001,44:659-673.
  • 9Parker PJ,Murra -Rust J.PKC at a glance[J].J Cell Sci,2004,117 (2):131-132.
  • 10Yu W,Niwa T,Fukasawa T,et al.Synergism of protein kinase A,protein kinase C,and myosin light-chain kinase in the secretory cascade of the pancreatic beta cell[J].Diabetes,2000,49:945-952.

二级参考文献9

  • 1徐康,林正.自由基对转录因子NF-κB活性的调节[J].医学研究生学报,2004,17(7):654-656. 被引量：13
  • 2American Diabetes Association.Diabetic Retinopathy[ J ].Diabetes Care,2002,25 (1):S90-S93.
  • 3Renu AK.Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats[ J ].Diabetes,2003,52 (3):818-823.
  • 4Aiello LP,Gardner TW,King GL,et al.Diabetic retinopathy[ J ].Diabetes Care,1998,21 (1):143-156.
  • 5Angelika B,Stephan S,Markus S,et al.diabetes-associated sustained activation of the transcription factor nuclear factor-κB[ J ].Diabetes,2001,50(12):2792-2808.
  • 6Kowluru RA,Koppolu P,Chakrabarti S,et al.Diabetes-induced activation of nuclear transcriptional factor in the retina,and its inhibition by antioxidants[ J ].Free Radic Res,2003,37 (11):1169-1180.
  • 7Giulio R,Wei-Hua L,Veronica A,et al.Kern,and mara lorenz activation of nuclear factor-κB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes[J].Diabetes,2002,51 (7):2241-2248.
  • 8Chen S,Mukherjee S,Chakraborty C,et al.High glucose-induced,endothelin-dependent,extracellular matrix protein synthesis is mediated via nuclear factor-κB and AP-1[ J].Am J Physiol Cell Physiol,2003,284(2):C263-C272.
  • 9Yoshida A,Yoshida S,Hata Y,et al.Suppression of retinal neovascularization by the NF-κB inhibitor pyrrolidine dithocarbamate in mice[J].Invest Ophthalmol Vis Sci,1999,40(7):1624-1629.

共引文献7

同被引文献144

引证文献12

二级引证文献80

长江大学学报（自科版）（下旬）
2010年 第1期

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